Neuroscience and Neurobiology Commons^™

Finding Brain Predictors Of Psychostimulant Medication Use In Adhd Using Machine Learning, Zoe Irene Hulce

Graduate College Dissertations and Theses

Psychostimulant medication is the first line of treatment for Attention deficit/hyperactivity disorder (ADHD). Despite the prevalence of ADHD, there is a lack of understanding of the underlying neurophysiological mechanisms of the disorder and its pharmacological treatments. Existing neuroimaging research shows some consistent structural differences in ADHD, but it can be difficult to discern what is relevant. Machine learning algorithms present a novel way of analyzing a large amount of data by making predictions based on pattern detection.

The present study applied an elastic-net logistic machine learning model to structural magnetic resonance imaging (sMRI) data from the Adolescent Brain Cognitive Development …