Neuroscience and Neurobiology Commons^™

Exosomes Isolated From Murine Astroglial Cells And Human Blood Samples Contain The Notch 1 Intracellular Domain, Nicholas Toker

Graduate College Dissertations and Theses

Notch 1 is an evolutionarily conserved cell signaling receptor with important functions ranging from control of stem cell proliferation and differentiation to regulation of angiogenesis. Accordingly, Notch 1 expression affects a diverse assortment of protein targets. Here, we explore the role that Notch 1 and related signaling molecules play in astrocyte cell biology. Specifically, we investigate exosomes and the transduction of Notch signaling in astrocytes. Exosomes are small (10-150 nm) vesicles secreted by most cell types and have been found to contain cargo ranging from small RNA species to full length transmembrane receptors. We report, for the first time to …