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Articles 1 - 4 of 4
Full-Text Articles in Neuroscience and Neurobiology
Perceiving Oldness In Parietal Cortex: Fmri Characterization Of A Parietal Memory Network, Adrian Gilmore
Perceiving Oldness In Parietal Cortex: Fmri Characterization Of A Parietal Memory Network, Adrian Gilmore
Arts & Sciences Electronic Theses and Dissertations
The manner in which the human brain recognizes certain stimuli as novel or familiar is a matter of ongoing investigation. The overarching goal of this dissertation is to improve our understanding of how this may be accomplished. More specifically, work contained herein focuses on a recently described "parietal memory network" (PMN; Gilmore et al., 2015) that shows opposite patterns of activity when perceiving novel or familiar stimuli: deactivating in response to novelty, and activating in response to familiarity. Critically, our understanding of this network is based on explicit memory tasks, in which subjects are deliberately instructed to learn or remember …
The Molecular And Cellular Basis For Cold Sensation, Daniel Brenner
The Molecular And Cellular Basis For Cold Sensation, Daniel Brenner
Arts & Sciences Electronic Theses and Dissertations
The ability to sense changes in temperature is crucial to surviving harsh environments. Over the last decade several ion channels that have been proposed to be cold sensitive have been identified, most notably TRPM8 and TRPA1. Although these molecules have been extensively studied in vitro, their exact roles in cold sensation in vivo are still debated. This uncertainty is in large part due to problems with the standard methods of testing cold sensitivity in vivo, which often rely on subjective measures of cold responsiveness. Experiments using these subjective measures have been repeated by different groups and have yielded conflicting results, …
Superoxide Dismutase 1: Novel Insights On Disease Models And Tissue Specificity In Amyotrophic Lateral Sclerosis, Matthew James Crisp
Superoxide Dismutase 1: Novel Insights On Disease Models And Tissue Specificity In Amyotrophic Lateral Sclerosis, Matthew James Crisp
Arts & Sciences Electronic Theses and Dissertations
Mutations in superoxide dismutase 1 (SOD1) are known to cause dominantly-inherited amyotrophic lateral sclerosis (ALS), a rapidly-fatal adult-onset neurodegenerative disorder defined by motor neuron loss and progressive paralysis. In the past twenty years, research into the disorder has been driven by the creation of numerous transgenic animal models that have yielded multiple theories on the pathogenesis of the disease. Patients and animal models with SOD1 mutations express the defective protein in every cell, yet the disease only affects tissues in the neuromuscular axis. In this dissertation, I present original work exploring two aspects of SOD1 ALS. The first details the …
The Murine Accessory Olfactory Bulb As A Model Chemosensory System: Experimental And Computational Analysis Of Chemosensory Representations, Gary Francis Hammen
The Murine Accessory Olfactory Bulb As A Model Chemosensory System: Experimental And Computational Analysis Of Chemosensory Representations, Gary Francis Hammen
Arts & Sciences Electronic Theses and Dissertations
A common challenge across sensory processing modalities is forming meaningful associations between the neural responses and the outside world. These neural representations of the world must then be integrated across different sensory systems contributing to each individuals perceptual experience. While there has been considerable study of sensory representations in the visual system of humans and multiple model organisms, other sensory domains, including olfaction, are less well understood. In this thesis, I set out to better understand the sensory representations of the mouse accessory olfactory system (AOS), a part of the olfactory system. The mouse AOS, our model chemosensory system, comprises …