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The Role Of Cholinergic Neurotransmission In Sensory Filtering And Sensorimotor Gating, Erin Azzopardi
The Role Of Cholinergic Neurotransmission In Sensory Filtering And Sensorimotor Gating, Erin Azzopardi
Electronic Thesis and Dissertation Repository
At every moment, our brain is bombarded with sensory information. How we filter and process sensory information is critical for daily functioning and cognition. Examples of sensory filtering include habituation (a progressive decrease in responding) and prepulse inhibition (PPI, gating of responding). Our aim is to understand the differential role acetylcholine (ACh) plays in these processes.
To study this we used both reflexive (acoustic startle response: ASR) and non-reflexive (locomotor) behaviours. PPI is hypothesized to occur via inhibitory cholinergic projections from the Pedunculopontine Tegmental Nucleus (PPT) to the startle pathway. The role of ACh in habituation of reflexive and non-reflexive …