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Reportinfluence Of Emotional States On Inhibitory Gating: Animal Models To Clinical Neurophysiology, Howard Cromwell
Reportinfluence Of Emotional States On Inhibitory Gating: Animal Models To Clinical Neurophysiology, Howard Cromwell
Howard Casey Cromwell
tIntegrating research efforts using a cross-domain approach could redefine traditional constructs used inbehavioral and clinical neuroscience by demonstrating that behavior and mental processes arise not fromfunctional isolation but from integration. Our research group has been examining the interface betweencognitive and emotional processes by studying inhibitory gating. Inhibitory gating can be measured viachanges in behavior or neural signal processing. Sensorimotor gating of the startle response is a well-usedmeasure. To study how emotion and cognition interact during startle modulation in the animal model,we examined ultrasonic vocalization (USV) emissions during acoustic startle and prepulse inhibition. Wefound high rates of USV emission during the …
Auditory Inhibitory Gating In Medial Prefrontal Cortex: Single Unit And Local Field Potential Analysis, Howard C. Cromwell
Auditory Inhibitory Gating In Medial Prefrontal Cortex: Single Unit And Local Field Potential Analysis, Howard C. Cromwell
Howard Casey Cromwell
Medial prefrontal cortex is a crucial region involved in inhibitory processes. Damage to the medial prefrontal cortex can lead to loss of normal inhibitory control over motor, sensory, emotional and cognitive functions. The goal of the present study was to examine the basic properties of inhibitory gating in this brain region in rats. Inhibitory gating has recently been proposed as a neurophysiological assay for sensory filters in higher brain regions that potentially enable or disable information throughput. This perspective has important clinical relevance due to the findings that gating is dramatically impaired in individuals with emotional and cognitive impairments (i.e. …