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Full-Text Articles in Neuroscience and Neurobiology
A Generative-Discriminative Approach To Human Brain Mapping, Deepanshu Wadhwa
A Generative-Discriminative Approach To Human Brain Mapping, Deepanshu Wadhwa
Electronic Thesis and Dissertation Repository
During everyday behaviours, the brain shows complex spatial patterns of activity. These activity maps are very replicable within an individual, but vary significantly across individuals, even though they are evoked by the same behaviour. It is unknown how differences in these spatial patterns relate to differences in behavior or function. More fundamentally, the structural, developmental, and genetic factors that determine the spatial organisation of these brain maps in each individual are unclear. Here we propose a new quantitative approach for uncovering the basic principles by which functional brain maps are organized. We propose to take an generative-discriminative approach to human …
Imaging Of Neurotransmitters And Small Molecules In Brain Tissues Using Laser Desorption/Ionization Mass Spectrometry Assisted With Zinc Oxide Nanoparticles., Chaochao Chen, Steven R Laviolette, Shawn N Whitehead, Justin B Renaud, Ken K-C Yeung
Imaging Of Neurotransmitters And Small Molecules In Brain Tissues Using Laser Desorption/Ionization Mass Spectrometry Assisted With Zinc Oxide Nanoparticles., Chaochao Chen, Steven R Laviolette, Shawn N Whitehead, Justin B Renaud, Ken K-C Yeung
Chemistry Publications
Inorganic nanostructured materials such as silicon, carbon, metals, and metal oxides have been explored as matrices of low-background signals to assist the laser desorption/ionization (LDI) mass spectrometric (MS) analysis of small molecules, but their applications for imaging of small molecules in biological tissues remain limited in the literature. Titanium dioxide is one of the known nanoparticles (NP) that can effectively assist LDI MS imaging of low molecular weight molecules (LMWM). TiO2 NP is commercially available as dispersions, which can be applied using a chemical solution sprayer. However, aggregation of NP can occur in the dispersions and the aggregated NP …