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Full-Text Articles in Neuroscience and Neurobiology
Investigating The Age-Dependent Impact Of Lactate Dehydrogenase On Cognition In Flies And Mice, Ariel Khaya Frame
Investigating The Age-Dependent Impact Of Lactate Dehydrogenase On Cognition In Flies And Mice, Ariel Khaya Frame
Electronic Thesis and Dissertation Repository
Lactate is a carbohydrate breakdown product typically produced in astrocytes, a type of glial cell, and transported to neurons within the brain. This type of metabolic coupling is commonly referred to as the astrocyte neuron lactate shuttle (ANLS). While numerous studies have shown that the ANLS is involved in cognition in mammals few have taken into consideration sex differences, changes with age, or evolutionary conservation in invertebrates. Lactate metabolism is controlled by the enzymatic interconversion of pyruvate and lactate in a reaction catalyzed by lactate dehydrogenase (LDH). In this thesis I examined cognitive changes across lifespan affected by genetic manipulation …
The Role Of H3k4 Methyltransferases In Drosophila Memory, Nicholas Raun
The Role Of H3k4 Methyltransferases In Drosophila Memory, Nicholas Raun
Electronic Thesis and Dissertation Repository
Gene transcription required for long-term memory requires the modification of histones. However, there are still many uncertainties about the identity and spatial expression of genes regulated by histone modifications during memory related processes. In this project I examined the role of Drosophila melanogaster methyltransferases Set1 and trx in courtship memory. Genetic knockdown of Set1 and trx in the mushroom body (MB) revealed that Set1 was necessary for short- and long-term memory, while trx was only required for long-term memory. Transcriptional profiling of MBs following trx-knockdown revealed expression changes in MB-enriched genes and genes involved in RNA processing. Among the …
Cerebral Lactate Metabolism And Memory: Implications For Alzheimer's Disease, Richard Andrew Harris
Cerebral Lactate Metabolism And Memory: Implications For Alzheimer's Disease, Richard Andrew Harris
Electronic Thesis and Dissertation Repository
Alzheimer’s disease (AD) is a neurodegenerative disease characterized by amyloid plaques that are comprised of aggregated amyloid-beta peptides. These toxic proteins promote mitochondrial dysfunction and neuronal cell death. A shift in metabolism away from oxidative phosphorylation and toward aerobic glycolysis, with the concomitant production of lactate, affords neurons a survival advantage against amyloid-beta toxicity. Recent evidence now suggests that aerobic glycolysis in the brain plays a critical role in supporting synaptic plasticity, learning, and memory. However, the role of aerobic glycolysis and lactate metabolism in AD-mediated cognitive decline is unknown. My objective was to test the hypotheses that aerobic glycolysis …