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- Astrocytes (1)
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Articles 1 - 4 of 4
Full-Text Articles in Neuroscience and Neurobiology
Quantitative Evaluation Of Microglial Activation And Vascularization In Suicide, Tatiana Pavlovna Schnieder
Quantitative Evaluation Of Microglial Activation And Vascularization In Suicide, Tatiana Pavlovna Schnieder
Dissertations, Theses, and Capstone Projects
Accumulated evidence points to immunological factors in psychiatric disorders. In a variety of chronic neurological disorders, exacerbation is associated with inflammation and a loss of integrity of the blood-brain barrier. Microglia, the principal brain immunological cells in the healthy state, respond to changes in the internal environment of the brain through a sequence of activated states. This study compared microglial phenotypes in the white matter of autopsy brains from 11 suicide victims and 25 subjects who died involuntarily. Both groups included cases with and without major psychiatric disorders, which were determined by PA interviews. Cases were matched for sex, age, …
Neurophysiological Bases Of Frequency Discrimination In Children With Auditory Processing Disorder Or Specific Language Impairment, Christine Rota-Donahue
Neurophysiological Bases Of Frequency Discrimination In Children With Auditory Processing Disorder Or Specific Language Impairment, Christine Rota-Donahue
Dissertations, Theses, and Capstone Projects
The purpose of this study was to determine if 10-12 year old children with Auditory Processing Disorder (APD) or Specific Language Impairment (SLI) could discriminate three different frequency changes behaviorally and electrophysiologically. Behavioral frequency discrimination and event-related potentials were examined using a 1000Hz pure tone base frequency. Typically developing children and children with APD or SLI differed in in their detection of frequency changes: behavioral results were below chance level and the MMN amplitude was smaller in the impaired population. Slight differences between children with APD and children with SLI were also found that might shed light on the controversy …
Using Otoacoustic Emissions To Evaluate Efferent Auditory Function In Humans, Simon Henin
Using Otoacoustic Emissions To Evaluate Efferent Auditory Function In Humans, Simon Henin
Dissertations, Theses, and Capstone Projects
The auditory system continually adapts to changes in the acoustic environment over short periods of time. This fine-tuning of its dynamics is mediated in part by the medial olivocochlear (MOC) bundle, a neural feedback loop which aids in the regulation of cochlear micro-mechanics. The ability to measure the response of the MOC system in humans may provide significant insight into unique cochlear functions, such as its sharp frequency selectivity and wide dynamic range. In humans the efferent system can be investigated non-invasively using otoacoustic emissions (OAEs). However, how OAEs can best be used to evaluate efferent function, the pitfalls associated …
Vegf Treatment During Status Epilepticus Alters Long-Term Hippocampal Astrocyte Morphology: A Detailed Description Of Astrocyte Morphology And Glutamate Transporter Patterns With And Without Administration Of Vegf And Seizure Induction, Janice Rene Lenzer
Dissertations, Theses, and Capstone Projects
VEGF treatment during pilocarpine-induced status epilepticus (SE) causes enduring preservation of behavioral function in rats in the absence of enduring neuroprotection (Nicoletti et al., 2010). In addition, VEGF treatment reduces hyperexcitability in hippocampal slices without altering neuronal membrane properties (McCloskey et al, 2005). Combined, these data suggest the possibility that other cells or mechanisms could be involved in the beneficial effects of VEGF during SE. Our laboratory is interested in the potential contribution of astrocytes to these effects. Astrocytes are not only reported to contribute to epileptiform discharges in the hippocampus (Tian et al., 2005; Kang et al., 2005) but …