Open Access. Powered by Scholars. Published by Universities.®
![Digital Commons Network](http://assets.bepress.com/20200205/img/dcn/DCsunburst.png)
Neuroscience and Neurobiology Commons™
Open Access. Powered by Scholars. Published by Universities.®
- Keyword
-
- Anesthetics (1)
- Anesthetics, General (1)
- Animals (1)
- BRAIN PLASTICITY (1)
- Default mode network (1)
-
- ENVIRONMENTAL ENRICHMENT (1)
- Electrodes (1)
- Electrodes, Implanted (1)
- Excitatory Postsynaptic Potentials (1)
- FETAL ALCOHOL SPECTRUM DISORDERS (1)
- Functional magnetic resonance imaging (1)
- General (1)
- Hippocampus (1)
- Implanted (1)
- Isoflurane (1)
- Kainic acid (1)
- Limbic network (1)
- Long-Evans (1)
- Male (1)
- NEURODEVELOPMENT (1)
- Nerve Net (1)
- Nucleus accumbens (1)
- Pentobarbital (1)
- Rats (1)
- Rats, Long-Evans (1)
- Status epilepticus (1)
- Synapses (1)
- Temporal lobe epilepsy (1)
- Publication
- Publication Type
Articles 1 - 4 of 4
Full-Text Articles in Neuroscience and Neurobiology
Disruption Of Hippocampal Multisynaptic Networks By General Anesthetics., Min-Ching Kuo, L Stan Leung
Disruption Of Hippocampal Multisynaptic Networks By General Anesthetics., Min-Ching Kuo, L Stan Leung
Physiology and Pharmacology Publications
BACKGROUND: Previous studies showed that synaptic transmission is affected by general anesthetics, but an anesthetic dose response in freely moving animals has not been done. The hippocampus provides a neural network for the evaluation of isoflurane and pentobarbital on multisynaptic transmission that is relevant to memory function.
METHODS: Male Long-Evans rats were implanted with multichannel and single electrodes in the hippocampus. Spontaneous local field potentials and evoked field potentials were recorded in freely behaving rats before (baseline) and after various doses of isoflurane (0.25 to 1.5%) and sodium pentobarbital (10 mg/kg intraperitoneal).
RESULTS: Monosynaptic population excitatory postsynaptic potentials at the …
Amelioration Of Prenatal Alcohol Effects By Environmental Enrichment In A Mouse Model Of Fasd, Aniruddho Chokroborty-Hoque
Amelioration Of Prenatal Alcohol Effects By Environmental Enrichment In A Mouse Model Of Fasd, Aniruddho Chokroborty-Hoque
Electronic Thesis and Dissertation Repository
Maternal alcohol consumption during pregnancy results in a spectrum of behavioural and cognitive deficits collectively known as Fetal Alcohol Spectrum Disorders (FASD). Currently, little is know about if and how the external environment may modulate these deficits. I have used C57BL/6 mice to study this interaction between prenatal alcohol exposure and the postnatal environment. Alcohol exposure during synaptogenesis produces high levels of anxiety-like traits and decreased memory performance. Alcohol-exposed mice (and matched unexposed controls) were put in 'environmentally-enriched' conditions of voluntary exercise, physical activities and cognitive stimulation to ascertain the effects of a positive postnatal environment. The results show that …
P27. Acute Impact Of An Extremely Low Frequency Magnetic Stimulus On Human Neurophysiological Function - Magnetophosphene Perception, Cadence M. Baker
P27. Acute Impact Of An Extremely Low Frequency Magnetic Stimulus On Human Neurophysiological Function - Magnetophosphene Perception, Cadence M. Baker
Western Research Forum
Background: Magnetophosphenes are classified as colourless, flickering lights that are perceived with closed eyes in the dark, and upon exposure to a magnetic field (MF). Uncertainties exist involving the MF threshold for magnetophosphene perception.
Methods: Forty subjects will be enrolled in this experiment aiming to provide a frequency-response curve of magnetophosphene perception under MF exposure. Subjects will sit in a whole head MF exposure device wearing a 64-channel MRI-compatible EEG cap. Subjects will be exposed to a MF with a frequency of 5-300 Hz, in the form of an increasing flux density ramp (increasing magnetic field flux density from 0-100 …
Resting State Functional Network Disruptions In A Kainic Acid Model Of Temporal Lobe Epilepsy., Ravnoor Singh Gill, Seyed M Mirsattari, L Stan Leung
Resting State Functional Network Disruptions In A Kainic Acid Model Of Temporal Lobe Epilepsy., Ravnoor Singh Gill, Seyed M Mirsattari, L Stan Leung
Physiology and Pharmacology Publications
We studied the graph topological properties of brain networks derived from resting-state functional magnetic resonance imaging in a kainic acid induced model of temporal lobe epilepsy (TLE) in rats. Functional connectivity was determined by temporal correlation of the resting-state Blood Oxygen Level Dependent (BOLD) signals between two brain regions during 1.5% and 2% isoflurane, and analyzed as networks in epileptic and control rats. Graph theoretical analysis revealed a significant increase in functional connectivity between brain areas in epileptic than control rats, and the connected brain areas could be categorized as a limbic network and a default mode network (DMN). The …