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Articles 1 - 9 of 9
Full-Text Articles in Neuroscience and Neurobiology
A Causal Inference Approach For Spike Train Interactions, Zach Saccomano
A Causal Inference Approach For Spike Train Interactions, Zach Saccomano
Dissertations, Theses, and Capstone Projects
Since the 1960s, neuroscientists have worked on the problem of estimating synaptic properties, such as connectivity and strength, from simultaneously recorded spike trains. Recent years have seen renewed interest in the problem coinciding with rapid advances in experimental technologies, including an approximate exponential increase in the number of neurons that can be recorded in parallel and perturbation techniques such as optogenetics that can be used to calibrate and validate causal hypotheses about functional connectivity. This thesis presents a mathematical examination of synaptic inference from two perspectives: (1) using in vivo data and biophysical models, we ask in what cases the …
Estimating Glutamate Transporter Surface Density In Mouse Hippocampal Astrocytes, Anca R. Radulescu, Annalisa Scimemi
Estimating Glutamate Transporter Surface Density In Mouse Hippocampal Astrocytes, Anca R. Radulescu, Annalisa Scimemi
Biology and Medicine Through Mathematics Conference
No abstract provided.
Data Assimilation For Conductance-Based Neuronal Models, Matthew Moye
Data Assimilation For Conductance-Based Neuronal Models, Matthew Moye
Dissertations
This dissertation illustrates the use of data assimilation algorithms to estimate unobserved variables and unknown parameters of conductance-based neuronal models. Modern data assimilation (DA) techniques are widely used in climate science and weather prediction, but have only recently begun to be applied in neuroscience. The two main classes of DA techniques are sequential methods and variational methods. Throughout this work, twin experiments, where the data is synthetically generated from output of the model, are used to validate use of these techniques for conductance-based models observing only the voltage trace. In Chapter 1, these techniques are described in detail and the …
Bifurcation Analysis Of A Photoreceptor Interaction Model For Retinitis Pigmentosa, Anca R. Radulescu
Bifurcation Analysis Of A Photoreceptor Interaction Model For Retinitis Pigmentosa, Anca R. Radulescu
Biology and Medicine Through Mathematics Conference
No abstract provided.
Spiking Activity In Networks Of Neurons Impacted By Axonal Swelling, Brian Frost, Stan Mintchev
Spiking Activity In Networks Of Neurons Impacted By Axonal Swelling, Brian Frost, Stan Mintchev
Biology and Medicine Through Mathematics Conference
No abstract provided.
Brain Network Structure And Interventions In A Computational Model Of Epilepsy, Joe Emerson
Brain Network Structure And Interventions In A Computational Model Of Epilepsy, Joe Emerson
Student Symposium
Some forms of drug-resistant epilepsy can only be treated via surgical intervention. This form of treatment requires the removal of a part of the brain identified as the seizure source. Current methods for surgical treatment are risky and many times unsuccessful. A deeper understanding of how brain connectivity facilitates seizure propagation is necessary for developing improved surgical techniques. Experimental limitations make certain clinical investigations of epilepsy difficult or impossible, but computational modeling offers a way forward when experimentation in living systems is impractical or unsafe. We used a full-hemisphere computational model for epilepsy to investigate the role of network structure …
Balanced Excitation And Inhibition Shapes The Dynamics Of A Neuronal Network For Movement And Reward, Anca R. Radulescu
Balanced Excitation And Inhibition Shapes The Dynamics Of A Neuronal Network For Movement And Reward, Anca R. Radulescu
Biology and Medicine Through Mathematics Conference
No abstract provided.
Wilson-Cowan Coupled Dynamics In A Model Of The Cortico-Striato-Thalamo-Cortical Circuit, Anca R. Radulescu
Wilson-Cowan Coupled Dynamics In A Model Of The Cortico-Striato-Thalamo-Cortical Circuit, Anca R. Radulescu
Biology and Medicine Through Mathematics Conference
No abstract provided.
Six Types Of Multistability In A Neuronal Model Based On Slow Calcium Current, Tatiana Malashchenko, Andrey Shilnikov, Gennady Cymbalyuk
Six Types Of Multistability In A Neuronal Model Based On Slow Calcium Current, Tatiana Malashchenko, Andrey Shilnikov, Gennady Cymbalyuk
Neuroscience Institute Faculty Publications
Background: Multistability of oscillatory and silent regimes is a ubiquitous phenomenon exhibited by excitable systems such as neurons and cardiac cells. Multistability can play functional roles in short-term memory and maintaining posture. It seems to pose an evolutionary advantage for neurons which are part of multifunctional Central Pattern Generators to possess multistability. The mechanisms supporting multistability of bursting regimes are not well understood or classified.
Methodology/Principal Findings: Our study is focused on determining the bio-physical mechanisms underlying different types of co-existence of the oscillatory and silent regimes observed in a neuronal model. We develop a low-dimensional model typifying the dynamics …