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Neuroscience and Neurobiology Commons™
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- Animals (1)
- Astrocyte (1)
- Brain Stem (1)
- Brainstem dorsal vagal complex (1)
- Diabetes Mellitus, Experimental (1)
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- Dorsal motor nucleus (1)
- Down-Regulation (1)
- Excitatory Postsynaptic Potentials (1)
- Functional plasticity (1)
- Hyperglycemia (1)
- Insulin (1)
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- Motor Neurons (1)
- NADPH oxidase (1)
- Nerve Net (1)
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- P53 (1)
- Parasympathetic Nervous System (1)
- Reactive Oxygen Sepcies (1)
- Retrovirus (1)
- TRPV Cation Channels (1)
- TRPV1 (1)
- Type 1 diabetes (1)
- Vagus (1)
- Vagus Nerve (1)
- Publication Type
Articles 1 - 2 of 2
Full-Text Articles in Neuroscience and Neurobiology
Functional Plasticity Of Central Trpv1 Receptors In Brainstem Dorsal Vagal Complex Circuits Of Streptozotocin-Treated Hyperglycemic Mice, Andrea Zsombok, Muthu D. Bhaskaran, Hong Gao, Andrei V. Derbenev, Bret N. Smith
Functional Plasticity Of Central Trpv1 Receptors In Brainstem Dorsal Vagal Complex Circuits Of Streptozotocin-Treated Hyperglycemic Mice, Andrea Zsombok, Muthu D. Bhaskaran, Hong Gao, Andrei V. Derbenev, Bret N. Smith
Physiology Faculty Publications
Emerging data indicate that central neurons participate in diabetic processes by modulating autonomic output from neurons in the dorsal motor nucleus of the vagus (DMV). We tested the hypothesis that synaptic modulation by transient receptor potential vanilloid type 1 (TRPV1) receptors is reduced in the DMV in slices from a murine model of type 1 diabetes. The TRPV1 agonist capsaicin robustly enhanced glutamate release onto DMV neurons by acting at preterminal receptors in slices from intact mice, but failed to do so in slices from diabetic mice. TRPV1 receptor protein expression in the vagal complex was unaltered. Brief insulin preapplication …
Upregulation Of Reactive Oxygen Species During The Retrovirus Life Cycle And Their Roles In A Mutant Of Moloney Murine Leukemia Virus, Ts1-Mediated Neurodegeneration, Soo Jin Kim
Dissertations & Theses (Open Access)
Viral invasion of the central nervous system (CNS) and development of neurological symptoms is a characteristic of many retroviruses. The mechanism by which retrovirus infection causes neurological dysfunction has yet to be fully elucidated. Given the complexity of the retrovirus-mediated neuropathogenesis, studies using small animal models are extremely valuable. Our laboratory has used a mutant moloney murine leukemia retrovirus, ts1-mediated neurodegneration. We hypothesize that astrocytes play an important role in ts1-induced neurodegeneration since they are retroviral reservoirs and supporting cells for neurons. It has been shown that ts1 is able to infect astrocytes in vivo and in …