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Role Of Neurogranin In The Regulation Of Calcium Binding To Calmodulin, Anuja Chandrasekar
Role Of Neurogranin In The Regulation Of Calcium Binding To Calmodulin, Anuja Chandrasekar
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Role of Neurogranin in the regulation of calcium binding to Calmodulin
Anuja Chandrasekar, B.S
Advisor: M. Neal Waxham, Ph.D
The overall goal of my project was to gain a quantitative understanding of how the interaction between two proteins neurogranin (RC3) and calmodulin (CaM) alters a fundamental property of CaM. CaM, has been extensively studied for more than four decades due to its seminal role in almost all biological functions as a calcium signal transducer. Calcium signals in cardiac and neuronal cells are exquisitely precise and enable activation of some processes while down-regulating others. CaM, with its four calcium binding sites, …