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Identifying Functional Imaging Markers In Psychosis Using Fmri, Ruiqi Wang
Identifying Functional Imaging Markers In Psychosis Using Fmri, Ruiqi Wang
MUSC Theses and Dissertations
Major types of psychotic disorders include schizophrenia (SCZ), bipolar disorder (BP) and schizoaffective disorder (SZA). These disorders have profound and overlapping symptoms with marked cognitive deficits, and their diagnosis relies on symptom clusters. The treatments for psychosis are usually focused on positive symptoms such as delusions and hallucinations. Although cognitive impairments underlie both positive and negative symptoms, functional brain imaging biomarkers that can reliably predict a patient's cognitive deficits are still lacking. Therefore, this project used functional MRI to explore the feasibility of using functional connectivity (FC) to predict cognitive performance.
A total of 207 subjects (BP: 79, SZ/SZA: 48, …