Open Access. Powered by Scholars. Published by Universities.®
Environmental Microbiology and Microbial Ecology Commons™
Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 1 of 1
Full-Text Articles in Environmental Microbiology and Microbial Ecology
Nutritional Regulation Of Sulfonamide Antibiotic Biodegradation By Microbacterium Sp. Strain C448, Tonya Malcolm
Nutritional Regulation Of Sulfonamide Antibiotic Biodegradation By Microbacterium Sp. Strain C448, Tonya Malcolm
Electronic Thesis and Dissertation Repository
Sulfonamide antibiotics are frequently released into the environment due to their widespread use in livestock production, imposing a potential selection pressure for the development and dissemination of sulfonamide resistance. Recently, a sulfonamide-degrading bacterium Microbacterium sp. Strain C448 was discovered, whose activity has the potential to be used as a sulfonamide removal strategy from agricultural soils. This research gains insight into the sulfonamide biodegradation pathway by 1) evaluating the nutritional regulation of sulfamethazine biodegradation and 2) undertaking a comparative proteomic analysis of cells grown in the presence and in the absence of sulfamethazine. The nutritional analyses revealed that increasing amounts of …