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Full-Text Articles in Microbiology
Biophysical Study Of The Sh2 Domain Of Human Tensin, Yogesh Mohan Kulkarni
Biophysical Study Of The Sh2 Domain Of Human Tensin, Yogesh Mohan Kulkarni
Doctoral Dissertations
Cell migration is a key characteristic of embryogenesis, inflammation, wound healing, tumor cell metastasis and a broad range of other normal and pathological processes. Accumulating evidence suggests that the protein tensin provides a physical link between transmembrane receptors, proteins commonly associated with signal transduction, and the actin cytoskeleton. Adhesion involves three broad classes of macromolecules: ExtraCellular Matrix (ECM) molecules, transmembrane adhesion receptors, and intracellular adhesion plaque proteins. Tensin is particularly enriched in Fibrillar Adhesions (FA's), though it is also present to a modest extent in Focal Contacts (FC's). Src Homology 2 (SH2) domains function in the transmission of molecular signals …