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Full-Text Articles in Microbiology
Htlv-Iii Serology In Hemophilia: Relationship With Immunologic Abnormalities, Joan C. Gill, Jay E. Menitove, Philip R. Anderson, James T. Casper, Sushilkumar G. Devare, Charles Wood, Stuart Adair, James Casey, Christi Scheffel, Robert R. Montgomery
Htlv-Iii Serology In Hemophilia: Relationship With Immunologic Abnormalities, Joan C. Gill, Jay E. Menitove, Philip R. Anderson, James T. Casper, Sushilkumar G. Devare, Charles Wood, Stuart Adair, James Casey, Christi Scheffel, Robert R. Montgomery
Nebraska Center for Virology: Faculty Publications
We investigated the relationship of the presence of antibodies to HTLV-III and immunologic abnormalities in patients with hemophilia. Serum antibodies to HTLV-III were analyzed by ELISA assay, immunoprecipitation of labeled cell extracts, and immunoprecipitation of purified HTLV-III p24. Thirty-four (61%) of the total group (n = 56) had antibody to HTLV-III; 34 (76%) of 45 patients given commercial factor VIII preparations were seropositive, compared with none of 11 patients treated exclusively with cryoprecipitate obtained from volunteer blood donors. Of patients who were seropositive for HTLV-III antibody, 94% had abnormal T4/T8 ratios, and 33% of those whose serum was antibody …