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Full-Text Articles in Microbiology
The Microbiome As An Environmental Risk Factor For Multiple Sclerosis, Theresa Montgomery
The Microbiome As An Environmental Risk Factor For Multiple Sclerosis, Theresa Montgomery
Graduate College Dissertations and Theses
Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system. The etiology of MS is complex and poorly understood; however, disease risk is likely combinatorial due to the effects of both genetics and environmental risk factors. A recently identified environment risk factor for MS is the gut microbiome. However, the specific gut microbiota associated with disease risk, onset and/or progression, their mechanisms of action, and impact of host genetics remain unclear. Leveraging the primary autoimmune mouse model of MS, experimental autoimmune encephalomyelitis (EAE), in a genetically diverse mouse model consisting of 29 unique genotypes, combined with gut …