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Full-Text Articles in Microbiology
Herpes Simplex Virus Glycoprotein D/Host Cell Surface Interaction Stimulates Chlamydia Trachomatis Persistence Via A Novel Pathway., Jennifer Vanover
Herpes Simplex Virus Glycoprotein D/Host Cell Surface Interaction Stimulates Chlamydia Trachomatis Persistence Via A Novel Pathway., Jennifer Vanover
Electronic Theses and Dissertations
When presented with certain unfavorable environmental conditions, C. trachomatis reticulate bodies (RBs) enter into a viable, yet noncultivable state called persistence. Two hallmarks of persistent chlamydiae are swollen, aberrantly shaped RBs, as viewed by transmission electron microscopy and a decrease in infectious progeny. Several models of chlamydial persistence have been described, including interferon-γ (IFN-γ), IFN-α, IFN-β, and tumor necrosis factor-α-exposure and nutrient deprivation. Previously, we established an in vitro co-infection model of two of the most common sexually transmitted pathogens in the United States, C. trachomatis and Herpes Simplex Virus-2 (HSV). Data from this tissue culture model indicate that: i) …
Identification Of Chlamydial Iron-Responsive Proteins During Intracellular Growth., Brian D. Dill
Identification Of Chlamydial Iron-Responsive Proteins During Intracellular Growth., Brian D. Dill
Electronic Theses and Dissertations
Chlamydia trachomatis is an obligate intracellular bacterium and the most prevalent cause of bacterial sexually transmitted disease. Genital chlamydial infections, marked by chronic, intense inflammation, can lead to genital tissue scarring and infertility and is a contributing factor to development of pelvic inflammatory disease and ectopic pregnancy. Iron is required as a cofactor for numerous highly conserved pathways, and nearly all studied organisms rely on iron for growth. In response to iron restriction, the chlamydial developmental cycle arrests at the intracellular reticulate body stage, resulting in a phenomenon termed persistence. Persistence likely plays a role in chlamydial pathogenesis through the …