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Full-Text Articles in Microbiology
The Molecular Mechanism Of Viral Transactivator Rta-Mediated Kaposi’S Sarcoma-Associated Herpesvirus (Kshv) Lytic Replication, Hui-Ju Wen
School of Biological Sciences: Dissertations, Theses, and Student Research
Kaposi’s sarcoma-associated herpesvirus (KSHV) is a member of the gamma-herpesvirinae subfamily and displays two distinct life phases, latency and lytic replication. Infection with KSHV mostly results in a latent state. A small population of infected cells can spontaneously undergo lytic phase, which is marked by abundant viral gene expression and production of infectious viral progeny. Lytic replication is important for transmission of KSHV in the population and development of diseases. RTA (replication and transcription activator) is a master regulator of KSHV lytic replication. Expression of RTA alone is sufficient to disrupt KSHV latency and initiate the lytic replication cascade. The …