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Full-Text Articles in Microbiology
Characterization Of Helicobacter Pylori Srnas Hpnc2525, Hpnc2600, And Hpnc2645, Brandon M. Flatgard
Characterization Of Helicobacter Pylori Srnas Hpnc2525, Hpnc2600, And Hpnc2645, Brandon M. Flatgard
EWU Masters Thesis Collection
Helicobacter pylori is a common microaerophilic gram-negative bacterium that infects approximately 50% of the human population. Although all H. pylori infections result in inflammation of the gastric epithelium, only 10-15% of infections are symptomatic and progress to severe gastric diseases such as gastric and duodenal ulcers, MALT lymphoma and gastric cancer. Different disease outcomes are due in part to genetic variations among H. pylori strains. Helicobacter pylori strains with a genomic region called the cytotoxin-associated pathogenicity island (cagPAI) are associated with an increased risk of severe disease. The cagPAI region encodes a type IV secretion system that transports the CagA …
The Bi-Directional Relationship Between Gut Microbiota And Autoimmunity, Trevor O. Kirby
The Bi-Directional Relationship Between Gut Microbiota And Autoimmunity, Trevor O. Kirby
EWU Masters Thesis Collection
Humans serve as a major reservoir for a vast number of microbiota. These microbes have evolved symbiotic relationships with humans due to their close proximity with their host. As a result, the immune system adapts to the microbiota thus modulating immunological function. Autoimmunity is a state in which there are aberrant immune responses produced against host tissue. Intestinal bacteria are directly impacted by instances of inflammation brought on by autoimmunity. The complicated nature between autoimmunity and bacterial modulation demonstrates a bi-directional relationship. Here, we utilize experimental autoimmune encephalomyelitis, a model for multiple sclerosis, to explore the bi-directional relationship that disease …