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Full-Text Articles in Microbiology
Oncolytic Viruses: Cancer Treatment Going Viral, Rhianna N. Bronson
Oncolytic Viruses: Cancer Treatment Going Viral, Rhianna N. Bronson
Chancellor’s Honors Program Projects
No abstract provided.
Whole Genome Sequencing As A Tool For Identifying Phenotypic Properties And Underlying Genetic Mechanisms In Staphylococcus Pseudintermedius, Matthew C. Riley
Whole Genome Sequencing As A Tool For Identifying Phenotypic Properties And Underlying Genetic Mechanisms In Staphylococcus Pseudintermedius, Matthew C. Riley
Doctoral Dissertations
Staphylococcus pseudintermedius is a Gram-positive bacterial opportunistic pathogen commonly associated with dermal infections in canines, but capable of causing serious disease in other species. Reports of human infections caused by S. pseudintermedius along with an increase in resistance to multiple antibiotics highlights the importance of this organism. Whole genome sequencing can allow large scale investigation of genetic mechanisms underlying phenotypic properties that contribute to the expansion of successful S. pseudintermedius clonal lineages.
The increase in multidrug and methicillin-resistant S. pseudintermedius (MRSP) may result from horizontal transfer of genetic material between bacterial isolates, yet is thought to be rare in Staphylococci …
Odontogenic Ameloblast-Associated Protein (Odam) Inhibits Growth And Migration Of Human Melanoma Cells And Elicits Pten Elevation And Inactivation Of Pi3k/Akt Signaling, James S. Foster, Lindsay M. Fish, Jonathan E. Phipps, Charles T. Bruker, James M. Lewis, John L. Bell, Alan Solomon, Daniel P. Kestler
Odontogenic Ameloblast-Associated Protein (Odam) Inhibits Growth And Migration Of Human Melanoma Cells And Elicits Pten Elevation And Inactivation Of Pi3k/Akt Signaling, James S. Foster, Lindsay M. Fish, Jonathan E. Phipps, Charles T. Bruker, James M. Lewis, John L. Bell, Alan Solomon, Daniel P. Kestler
Faculty Publications and Other Works -- UT Graduate School of Medicine
Background
The Odontogenic Ameloblast-associated Protein (ODAM) is expressed in a wide range of normal epithelial, and neoplastic tissues, and we have posited that ODAM serves as a novel prognostic biomarker for breast cancer and melanoma. Transfection of ODAM into breast cancer cells yields suppression of cellular growth, motility, and in vivo tumorigenicity. Herein we have extended these studies to the effects of ODAM on cultured melanoma cell lines.
Methods
The A375 and C8161 melanoma cell lines were stably transfected with ODAM and assayed for properties associated with tumorigenicity including cell growth, motility, and extracellular matrix adhesion. In addition, ODAM–transfected cells …