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Sos Response Induces Persistence To Fluoroquinolones In Escherichia Coli, Tobias Dörr, Kim Lewis, Marin Vulić
Sos Response Induces Persistence To Fluoroquinolones In Escherichia Coli, Tobias Dörr, Kim Lewis, Marin Vulić
Marin Vulić
Bacteria can survive antibiotic treatment without acquiring heritable antibiotic resistance. We investigated persistence to the fluoroquinolone ciprofloxacin in Escherichia coli. Our data show that a majority of persisters to ciprofloxacin were formed upon exposure to the antibiotic, in a manner dependent on the SOS gene network. These findings reveal an active and inducible mechanism of persister formation mediated by the SOS response, challenging the prevailing view that persisters are pre-existing and formed purely by stochastic means. SOS-induced persistence is a novel mechanism by which cells can counteract DNA damage and promote survival to fluoroquinolones. This unique survival mechanism may be …
Sos Response Induces Persistence To Fluoroquinolones In Escherichia Coli, Tobias Dörr, Kim Lewis, Marin Vulić
Sos Response Induces Persistence To Fluoroquinolones In Escherichia Coli, Tobias Dörr, Kim Lewis, Marin Vulić
Kim Lewis
Bacteria can survive antibiotic treatment without acquiring heritable antibiotic resistance. We investigated persistence to the fluoroquinolone ciprofloxacin in Escherichia coli. Our data show that a majority of persisters to ciprofloxacin were formed upon exposure to the antibiotic, in a manner dependent on the SOS gene network. These findings reveal an active and inducible mechanism of persister formation mediated by the SOS response, challenging the prevailing view that persisters are pre-existing and formed purely by stochastic means. SOS-induced persistence is a novel mechanism by which cells can counteract DNA damage and promote survival to fluoroquinolones. This unique survival mechanism may be …