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Laboratory and Basic Science Research Commons™
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Articles 1 - 14 of 14
Full-Text Articles in Laboratory and Basic Science Research
Methods Of Euthanasia In Laboratory Animals, Jaiden L. Corley
Methods Of Euthanasia In Laboratory Animals, Jaiden L. Corley
Williams Honors College, Honors Research Projects
The current honors research project will focus on the current use of carbon dioxide (CO2) as a means of euthanizing laboratory mice. CO2 is commonly used as a means of euthanizing laboratory animals and has been a standard of practice for mamy years. it is regarded as fast, painless, and efficient in overwhelming the respiratory control centers of the brainstem and resulting in respiratory depression and death. However, there continues to be debate and ongoing research regarding the 'humaneness' of this approach to euthanasia, and the American Veterinary Medicine Association (AVMA) suggests the inclusion of isoflurane (a volatile anesthetic) as …
The Impact Of Seasonal Variation On Body Morphology In Temnothorax Curvispinosus, Chelsea Kalb
The Impact Of Seasonal Variation On Body Morphology In Temnothorax Curvispinosus, Chelsea Kalb
Williams Honors College, Honors Research Projects
This study examines how seasonal variations affect the morphology of Temnothorax curvispinosus (acorn ants) by comparing workers hatched in the spring and in the fall. Colonies will be collected from the Bath Nature Preserve in May and September to represent the different seasonal groups. Morphological traits, such as the head, mesosoma, gaster, antennae, and leg, will be measured using a microscope and an image analysis software. The morphological measurements from each group will then be compared using ANOVA. By exploring how environmental variation influences developmental outcomes in acorn ants, this research contributes to our understanding of phenotypic plasticity and insect …
Impact Of Tetrahydrocannabinol (Thc) On Daphnia Magna Heart Rate, Ashley Cosgrave
Impact Of Tetrahydrocannabinol (Thc) On Daphnia Magna Heart Rate, Ashley Cosgrave
Williams Honors College, Honors Research Projects
Marijuana (Cannabis) is currently federally illegal within the United States and classified as a Schedule I drug. This leaves a large research gap on the impacts of Tetrahydrocannabinol (THC) use. Daphnia magna are frequently used as a model organism for the human heart and toxicology screenings due to their myogenic heart, similarities in physiological pathways, and sensitivity to toxins. As such, in order to bridge the research gap and uncover potential use of Daphnia magna as a model organism for humans in regard to impact on heart rate, we hypothesized that if Daphnia magna possess CB1 receptors or an equivalent …
Hip Strengthening In Female Collegiate Soccer Players: Effects Of Gluteus Medius Strengthening On Biodex Balance Scores, Caitlin Bruni, Morgan Shansky
Hip Strengthening In Female Collegiate Soccer Players: Effects Of Gluteus Medius Strengthening On Biodex Balance Scores, Caitlin Bruni, Morgan Shansky
Williams Honors College, Honors Research Projects
The purpose of this study is to examine the effects of gluteus medius (Gmed) strengthening program on single leg stability in collegiate female soccer players. Given the role of Gmed in stabilizing the hip, improving its strength may reduce lower extremity injury risk. Weakness in Gmed has been linked to conditions such as Anterior Cruciate Ligament (ACL) tears and Patellofemoral pain syndrome (PFPS). This study investigates whether an 8-week strength program improves single-leg stability, measured using the Biodex Balance System. Thirty-three female soccer players (18-23 years) from The University of Akron were recruited, with 22 completing the study. Participants underwent …
Crayfish Tube-Feeding Methodology, Phoenix Johnson
Crayfish Tube-Feeding Methodology, Phoenix Johnson
Williams Honors College, Honors Research Projects
The purpose of this paper was to use a tube feeding method on crayfish to expose them to substances through ingestion rather than the gill. This was done to mimic human ingestion of substance to aid in crayfish research involving substances that are normally ingestion. This was done by using a pipette to inject grains of sand into the mouth of the crayfish. To determine if the method worked and successfully went into the stomach the grains of sand were recovered and counted under a microscope after certain increments of time post injection.
Amphisbaenian Head Movement And Burrowing Forces In Damp Granular Media, Jacob Newell
Amphisbaenian Head Movement And Burrowing Forces In Damp Granular Media, Jacob Newell
Williams Honors College, Honors Research Projects
Damp granular media is a difficult environment to study because it is both practically complex and it lacks equations which fully describe its behavior. In this study, an oscillatory lateral head movement and its effects while penetrating damp granular media were tested using a robophysical model. This experimental research was inspired by the burrowing behavior of the clade Amphisbaenia, a group of usually limbless squamates that employ a variety of different burrowing behaviors, but it can apply to a wide range of burrowers. This research could help with both human burrowing technologies and the further investigation of animal behaviors.
The Effect Of Alpha Lipoic Acid On Cardiac Autonomic Neuropathy In Danio Rerio, Sophia Scott
The Effect Of Alpha Lipoic Acid On Cardiac Autonomic Neuropathy In Danio Rerio, Sophia Scott
Williams Honors College, Honors Research Projects
Even though poor glycemic control puts diabetics at risk for a variety of disease complications, there are many barriers to achieving adequate blood glucose regulation. Diabetic cardiac autonomic neuropathy (CAN) is a progressive autonomic denervation of the cardiovascular system resulting from chronic hyperglycemia and characterized by orthostatic hypertension, sinus tachycardia, low heart rate variability, and fatal arrhythmias. Available CAN therapeutics are limited to symptom alleviation, and do not prevent or reverse cardiac nerve damage. Limited evidence from clinical trials suggests the antioxidant Alpha Lipoid Acid (ALA) prevents CAN progression (Lee et al., 2017; Serhiyenko et al., 2020; Tankova, Koev & …
The Accuracy Of Recreational Athletes In Self Detecting Ventilation Threshold During A Maximal Exercise Test, Andrew Biegner
The Accuracy Of Recreational Athletes In Self Detecting Ventilation Threshold During A Maximal Exercise Test, Andrew Biegner
Williams Honors College, Honors Research Projects
INTRODUCTION: Ventilatory threshold (VT) is where minute ventilation (VE) increases nonlinearly with increasing exercise intensity. Prior studies have shown that subjects can recognize VT by changes in breathing during exercise. Teaching recreational athletes to use VT as a training method could result in better quality training. PURPOSE: Determine if recreational athletes can accurately perceive changes in ventilation associated with VT during maximal exercise testing. METHODS: Subjects were recruited (n=20, age= 20.5 ± 1.7 yrs.) to participate in the study. Subjects performed a modified maximal treadmill protocol with gas analysis. Subjects indicated when they noticed a considerable change …
The Effects Of Increasing Positively Charged Metal Ions Within Synovial Fluid, Kandisi Anyabwile
The Effects Of Increasing Positively Charged Metal Ions Within Synovial Fluid, Kandisi Anyabwile
Williams Honors College, Honors Research Projects
Osteoarthritis is a degenerative joint disease that affects 10% of men and 13% of women over age of 60. It is the degradation of the cartilage between two bones; obesity, age, overuse, or injury are major contributors to the development of this disease. The joint is incapsulated by the synovial sac filled with a viscous solution that aids in lubrication referred to as synovial fluid. If the synovial sac is ruptured due to injury, positive ions (K+, Na+, Ca2+, and Fe3+) may affect viscoelastic properties within the sac. The purpose of this …
The Cardiovascular Response To Acute Hypoxic Conditions In Danio Rerio, Bryce Fetterman
The Cardiovascular Response To Acute Hypoxic Conditions In Danio Rerio, Bryce Fetterman
Williams Honors College, Honors Research Projects
There are many fish that can withstand hypoxia levels. One in particular is the zebrafish (Danio rerio). The zebrafish is a small-sized, Cyprinid teleost fish, and has been used in a laboratory setting for many reasons. A few reasons being that they are widely available, easy to care for, and the cost for these fish are very low. There are various reasons why these fish are used as a model. One main reason is because their cardiovascular system is one of the first developing organs. This allows for better resolution when studying the cardiovascular system. The purpose of …
Determination Of Iron-Reducing Bacterial Activities In Lake Sediments., Alexandra Kahn
Determination Of Iron-Reducing Bacterial Activities In Lake Sediments., Alexandra Kahn
Williams Honors College, Honors Research Projects
Algal blooms are growing rampantly in lacustrine systems due to an increase of phosphorus, a nutrient for algae. Phosphorus is being released into the environment causing overpopulation and eutrophication which damages the ecosystem. The availability of phosphorus is affected by the solubility of iron which is regulated through iron reducing and iron oxidizing bacteria. Phosphorus adheres to insoluble Fe(III), which prohibits algae from utilizing it, while phosphorus does not attach to soluble Fe(II) and therefore it remains available to algae. The purpose of this study was to determine how bacteria influence iron solubility and what are the ideal environmental conditions …
Non-Invasive Method For Leptin Supplementation In Zebrafish (Danio Rerio), Regan Mcnamara
Non-Invasive Method For Leptin Supplementation In Zebrafish (Danio Rerio), Regan Mcnamara
Williams Honors College, Honors Research Projects
I tested the hypothesis that recombinant leptin protein can be introduced to zebrafish in vivo through non-invasive soaking in a solution containing the protein. One way to study various molecules’ effects in vivo is through intraperitoneal or intracerebroventricular injections during the embryonic or larval stage, which is invasive, difficult to administer, and can have a high mortality rate. 48 hours post fertilization (hpf) zebrafish were soaked in a His-tagged recombinant leptin protein solution at 10 nM and 100 nM concentrations (produced by Genscript). After soaking, zebrafish larvae were washed extensively to remove all recombinant protein on their exterior before homogenization. …
Effects Of Acute Hypoxia On Danio Rerio, Karly Crail
Effects Of Acute Hypoxia On Danio Rerio, Karly Crail
Williams Honors College, Honors Research Projects
The purpose of this research experiment was to determine the effects of acute hypoxia on the embryonic zebrafish (Danio rerio) cardiovascular system and assess the critical oxygen level at which embryonic function is compromised. This goal was achieved by exposing embryos to decreasing oxygen concentrations, (6.0 mg/L-0 mg/L) and observing the heart under an inverted microscope. Data analysis was conducted to determine end systolic volume, end diastolic volume, stroke volume, heart rate, and cardiac output. It was hypothesized that hypoxia would stimulate cardiac activity, because in early developmental stages, tissues are supplied with oxygen through bulk diffusion, and …
Identification And Quantification Of Zooplankton In Ne Ohio Drinking Water Reservoirs, Michael Vigorito
Identification And Quantification Of Zooplankton In Ne Ohio Drinking Water Reservoirs, Michael Vigorito
Williams Honors College, Honors Research Projects
Cyanobacteria, or blue-green algae, are present in most freshwater ecosystems and are usually harmless. When these algae swell in numbers, they release harmful toxins that can be detrimental to animal and human health, and can destroy ecosystems. For this reason, many scientists and engineers have studied these harmful algal blooms in an attempt to predict, prevent, or control them to keep people and ecosystems safe. One of the variables in this investigation is the presence and quantity of zooplankton. These animals could play an important role in the prevalence of cyanobacteria, but more information is needed to determine what that …