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Articles 1 - 9 of 9
Full-Text Articles in Laboratory and Basic Science Research
Rapid Golgi Stain For Dendritic Spine Visualization In Hippocampus And Prefrontal Cortex, Maya Frankfurt, Rachel E. Bowman
Rapid Golgi Stain For Dendritic Spine Visualization In Hippocampus And Prefrontal Cortex, Maya Frankfurt, Rachel E. Bowman
Psychology Faculty Publications
Golgi impregnation, using the Golgi staining kit with minor adaptations, is used to impregnate dendritic spines in the rat hippocampus and medial prefrontal cortex. This technique is a marked improvement over previous methods of Golgi impregnation because the premixed chemicals are safer to use, neurons are consistently well impregnated, there is far less background debris, and for a given region, there are extremely small deviations in spine density between experiments. Moreover, brains can be accumulated after a certain point and kept frozen until further processing. Using this method any brain region of interest can be studied. Once stained and cover …
Sex Differences In Chronic Stress Effects On Cognition In Rodents, Victoria N. Luine, Juan Gomez, Kevin D. Beck, Rachel E. Bowman
Sex Differences In Chronic Stress Effects On Cognition In Rodents, Victoria N. Luine, Juan Gomez, Kevin D. Beck, Rachel E. Bowman
Psychology Faculty Publications
Chronic stress causes deleterious changes in physiological function in systems ranging from neural cells in culture to laboratory rodents, sub-human primates and humans. It is notable, however, that the vast majority of research in this area has been conducted in males. In this review, we provide information about chronic stress effects on cognition in female rodents and contrast it with responses in male rodents. In general, females show cognitive resilience to chronic stressors which impair male cognitive function using spatial tasks including the radial arm maze, radial arm water maze, Morris water maze, Y-maze and object placement. Moreover, stress often …
Developing A Catalog Of Socio-Sexual Behaviors Of Beluga Whales ( Delphinapterus Leucas ) In The Care Of Humans, Heather M. Hill, Sarah Dietrich, Deirdre Yeater, Mariyah Mckinnon, Malin Miller, Steve Aibel, Al Dove
Developing A Catalog Of Socio-Sexual Behaviors Of Beluga Whales ( Delphinapterus Leucas ) In The Care Of Humans, Heather M. Hill, Sarah Dietrich, Deirdre Yeater, Mariyah Mckinnon, Malin Miller, Steve Aibel, Al Dove
Psychology Faculty Publications
The repertoire of socio-sexual and sexual behaviors of cetaceans is relatively unknown. The purpose of the current study was to advance the existing knowledge of socio-sexual behavior of beluga whales through the development of a behavioral catalog that lists the full repertoire of sexual and socio-sexual behaviors. A behavioral catalog was developed initially from 800 hours of observations, collected across a 7-year period from 11 belugas ranging in age (birth to 30+ years), sex, and social groupings. Using this behavioral catalog, observations of eight additional belugas housed between two other facilities were coded for socio-sexual and sexual behaviors. Socio-sexual and …
Adolescent Bisphenol-A Exposure Decreases Dendritic Spine Density: Role Of Sex And Age, Rachel E. Bowman, Victoria N. Luine, Hameda Khandaker, Joseph J. Villafane, Maya Frankfurt
Adolescent Bisphenol-A Exposure Decreases Dendritic Spine Density: Role Of Sex And Age, Rachel E. Bowman, Victoria N. Luine, Hameda Khandaker, Joseph J. Villafane, Maya Frankfurt
Psychology Faculty Publications
Bisphenol-A (BPA), a common environmental endocrine disruptor, modulates estrogenic, androgenic, and anti-androgenic effects throughout the lifespan. We recently showed that low dose BPA exposure during adolescence increases anxiety and impairs spatial memory independent of sex. In the current study, six week old Sprague Dawley rats (n=24 males, n=24 females) received daily subcutaneous injections (40 µg/kg bodyweight) of BPA or vehicle for one week. Serum corticosterone levels in response to a 1 h restraint stress and spine density were examined at age 7 (cohort 1) and 11 (cohort 2) weeks. Adolescent BPA exposure did not alter stress dependent corticosterone responses but …
Observational Learning In Wild And Captive Dolphins, Deirdre Yeater, Stan A. Kuczaj Ii
Observational Learning In Wild And Captive Dolphins, Deirdre Yeater, Stan A. Kuczaj Ii
Psychology Faculty Publications
Many non-human species imitate the behavior of others, and dolphins seem particularly adept at this form of observational learning. Evidence for observational learning in wild dolphins is rare, given the difficulty of observing individual wild animals in sufficient detail to eliminate other possible explanations of purported imitation. Consequently, much of the evidence supporting observational learning in dolphins has involved animals in captive settings. This research suggests that dolphins have an affinity for mimicry, and that they are more successful at observational learning if they choose to imitate another rather than being asked to do so. These results, combined with those …
Play And Adversity: How The Playful Mammalian Brain Withstands Threats And Anxieties, Stephen M. Siviy
Play And Adversity: How The Playful Mammalian Brain Withstands Threats And Anxieties, Stephen M. Siviy
Psychology Faculty Publications
Most mammals play, but they do so in a dangerous world. The dynamic relationship between the stresses created by their world and the activity of play helps to explain the evolution of play in mammals, as the author demonstrates in evidence garnered from experiments that introduce elements of fear to rats at play. The author describes the resulting fearful behavior and quantifies the fluctuation in play that results, and then he investigates how these are modified by increased maternal care or the use of benzodiazepines. In conclusion, he discusses how such research can help shed light on the neurobiology underlying …
Aged Rats: Sex Differences And Responses To Chronic Stress, Rachel E. Bowman, Neil J. Maclusky, Samantha Diaz-Weinstein, Mark C. Zrull, Victoria N. Luine
Aged Rats: Sex Differences And Responses To Chronic Stress, Rachel E. Bowman, Neil J. Maclusky, Samantha Diaz-Weinstein, Mark C. Zrull, Victoria N. Luine
Psychology Faculty Publications
Cognitive, as well as physiological, sex differences exist in young adult rats under both basal conditions and following chronic stress; however, few studies have examined whether sex differences remain in aged subjects and whether responses to stress are altered. We compared aged male and female Fischer 344 rats (21.5 months at testing) without stress and when given 21 days of restraint for 6 h/day on locomotion, anxiety-related behaviors, object recognition (non-spatial memory), object placement (spatial memory), body weight and serum steroid hormone levels. Control (unstressed) females had lower levels of estradiol and testosterone and higher corticosterone than males, and stress …
Sexually Dimorphic Effects Of Prenatal Stress On Cognition, Hormonal Responses, And Central Neurotransmitters, Rachel E. Bowman, Neil J. Maclusky, Yessenia Sarmiento, Maya Frankfurt, Marisa Gordon, Victoria N. Luine
Sexually Dimorphic Effects Of Prenatal Stress On Cognition, Hormonal Responses, And Central Neurotransmitters, Rachel E. Bowman, Neil J. Maclusky, Yessenia Sarmiento, Maya Frankfurt, Marisa Gordon, Victoria N. Luine
Psychology Faculty Publications
Exposure to stress during gestation results in physiological and behavioral alterations that persist into adulthood. This study examined the effects of prenatal stress on the postnatal expression of sexually differentiated cognitive, hormonal, and neurochemical profiles in male and female rats. Pregnant dams were subjected to restraint stress three times daily for 45 min during d 14-21 of pregnancy. The offspring of control and prenatally stressed dams were tested for anxiety-related and cognitive behaviors, stress and gonadal steroid hormone levels, as well as monoamines and metabolite levels in selected brain regions. Postnatal testosterone levels (measured at 1 and 5 d) did …
Extinction Of Fear-Potentiated Startle: Blockade By Infusion Of An Nmda Antagonist Into The Amygdala, Michael Davis, William A. Falls, Mindy Miserendino
Extinction Of Fear-Potentiated Startle: Blockade By Infusion Of An Nmda Antagonist Into The Amygdala, Michael Davis, William A. Falls, Mindy Miserendino
Psychology Faculty Publications
Data derived from in vitro preparations indicate that NMDA receptors play a critical role in synaptic plasticity in the CNS. More recently, in vivo pharmacological manipulations have suggested that an NMDA-dependent process may be involved in specific forms of behavioral plasticity. All of the work thus far has focused on the possible role of NMDA receptors in the acquisition of responses. However, there are many examples in the behavioral literature of learning-induced changes that involve the reduction or elimination of a previously acquired response. Experimental extinction is a primary example of the elimination of a learned response. Experimental extinction is …