Other Kinesiology Commons^™

Il-15 Activates The Jak3/Stat3 Signaling Pathway To Mediate Glucose Uptake In Skeletal Muscle Cells, James E. Krolopp, Shantaé M. Thornton, Marcia J. Abbott

Health Sciences and Kinesiology Faculty Articles

Myokines are specialized cytokines that are secreted from skeletal muscle (SKM) in response to metabolic stimuli, such as exercise. Interleukin-15 (IL-15) is a myokine with potential to reduce obesity and increase lean mass through induction of metabolic processes. It has been previously shown that IL-15 acts to increase glucose uptake in SKM cells. However, the downstream signals orchestrating the link between IL-15 signaling and glucose uptake have not been fully explored. Here we employed the mouse SKM C2C12 cell line to examine potential downstream targets of IL-15-induced alterations in glucose uptake. Following differentiation, C2C12 cells were treated overnight with 100 …

An Assessment Of Scholastic Basketball Programs: Administration, Facilities, And Support, Leah Cannady

Mahurin Honors College Capstone Experience/Thesis Projects

The main purpose of this study was to validate the survey insturement created to evaluate various aspects of scholastic basketball programs—including but not limited to administration, facilities, and support. All boys and girls head basketball coaches in South Dakota were administered an electronic survey created for the study. To incentivize participation, respondents could choose to be entered to win a monetary donation of $250 to their basketball program. Descriptive statstics were used to summarize respondent demographics and other statistical measures were used to indicate reliability and validity of the survey instrument. Cronbach’s alpha was calculated at .711 and Pearson’s correlation …

Encoding Of Saltatory Tactile Velocity In The Adult Orofacial Somatosensory System, Rebecca Custead

College of Education and Human Sciences: Dissertations, Theses, and Student Research

Processing dynamic tactile inputs is a key function of somatosensory systems. Spatial velocity encoding mechanisms by the nervous system are important for skilled movement production and may play a role in recovery of motor function following neurological insult. Little is known about tactile velocity encoding in trigeminal networks associated with mechanosensory inputs to the face, or the consequences of movement.

High resolution functional magnetic resonance imaging (fMRI) was used to investigate the neural substrates of velocity encoding in the human orofacial somatosensory system during unilateral saltatory pneumotactile inputs to perioral hairy skin in 20 healthy adults. A custom multichannel, scalable …

Time Course Of Changes In Neuromuscular Parameters During Fatiguing High-Load And Low-Load Concentric Dynamic Constant External Resistance Leg Extension Muscle Actions, Cory M. Smith

Department of Nutrition and Health Sciences: Dissertations, Theses, and Student Research

The purpose of this study was to simultaneously assess electromyographic (EMG) and mechanomyographic (MMG) signals to examine the time course of changes in EMG amplitude, EMG frequency, MMG amplitude, and MMG frequency from the vastus lateralis (VL), vastus medialis (VM), and rectus femoris (RF) muscles during high-load (70%1 repetitions maximum; 1-RM) and low-load (30% 1-RM) concentric, dynamic constant external resistance (DCER) leg extension muscle actions to failure. Twelve men performed two randomized visits consisting of either 30 or 70% 1-RM DCER leg extension muscle actions to failure. Maximal voluntary isometric contractions (MVIC) and 1-RM measurements were performed before and after …

Il-15 Mediates Mitochondrial Activity Through A Ppar𝛿-Dependent-Ppar𝛼-Independent Mechanism In Skeletal Muscle Cells, Shantaé M. Thornton, James E. Krolopp, Marcia J. Abbott

Health Sciences and Kinesiology Faculty Articles

Molecular mediators of metabolic processes, to increase energy expenditure, have become a focus for therapies of obesity. The discovery of cytokines secreted from the skeletal muscle (SKM), termed “myokines,” has garnered attention due to their positive effects on metabolic processes. Interleukin-15 (IL-15) is a myokine that has numerous positive metabolic effects and is linked to the PPAR family of mitochondrial regulators. Here, we aimed to determine the importance of PPAR𝛼 and/or PPAR𝛿 as targets of IL-15 signaling. C2C12 SKM cells were differentiated for 6 days and treated every other day with IL-15 (100 ng/mL), a PPAR𝛼 inhibitor (GW-6471), a PPAR𝛿 …