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Spinal Motor Neuron Excitability During Fatigue, Nathalie Cecire
Spinal Motor Neuron Excitability During Fatigue, Nathalie Cecire
Theses and Dissertations (Comprehensive)
Fatigue during sustained or repeated muscular contractions can be from contractile failure within the muscle or reduced excitability in the supraspinal and spinal motor neurons. However, spinal motor neurons can also compensate for fatigue. We speculate that one way the spinal motor neuron compensates for fatigue is through an increase in excitability via the activation of persistent inward currents (PIC). In other conditions where there is a reduction in descending drive, such as during spinal cord injury and aging, there are adaptions of the spinal motor neurons to have elevated PIC amplitudes or towards a greater prevalence of PIC, respectively. …