Exercise Science Commons^™

Autophagy And Aging: Maintaining The Proteome Through Exercise And Caloric Restriction, Kurt A. Escobar, Nathan H. Cole, Christine M. Mermier, Trisha A. Vandusseldrop

Faculty and Research Publications

Accumulation of dysfunctional and damaged cellular proteins and organelles occursduring aging, resulting in a disruption of cellular homeostasis and progressive degen-eration and increases the risk of cell death. Moderating the accrual of these defunctcomponents is likely a key in the promotion of longevity. While exercise is knownto promote healthy aging and mitigate age‐related pathologies, the molecular under-pinnings of this phenomenon remain largely unclear. However, recent evidencessuggest that exercise modulates the proteome. Similarly, caloric restriction (CR), aknown promoter of lifespan, is understood to augment intracellular protein quality.Autophagy is an evolutionary conserved recycling pathway responsible for thedegradation, then turnover of cellular proteins …