Exercise Science Commons^™

Determinants Of Erythropoietin Release In Response To Short-Term Hypobaric Hypoxia, Ri Li Ge, S. Witkowski, Y. Zhang, C. Alfrey, M. Sivieri, T. Karlsen, G. K. Resaland, M. Harber, J. Stray-Gundersen, B. D. Levine

Exercise and Sport Studies: Faculty Publications

We measured blood erythropoietin (EPO) concentration, arterial O2 saturation (SaO2), and urine PO2 in 48 subjects (32 men and 16 women) at sea level and after 6 and 24 h at simulated altitudes of 1,780, 2,085, 2,454, and 2,800 m. Renal blood flow (Doppler) and Hb were determined at sea level and after 6 h at each altitude (n = 24) to calculate renal O2 delivery. EPO increased significantly after 6 h at all altitudes and continued to increase after 24 h at 2,454 and 2,800 m, although not at 1,780 or 2,085 m. The increase in EPO varied markedly …