Kinesiology Commons^™

Glycogen Resynthesis And Recovery From Exercise: Effects Of Very-Long Chain Acyl-Coenzyme, A Dehydrogenase Deficiency, Kyle E. Johnson

Inquiry: The University of Arkansas Undergraduate Research Journal

Disorders of fatty acid metabolism pose a variety of problems including hypoglycemia, muscle weakness, muscle cramping, rhabdomyolysis, and, in the most severe cases, death. Individuals with a deficiency of very-long-chain acyl-CoA dehydrogenase (VLCAD ), the enzyme initiating the oxidation of very-long-chain fatty acids, are particularly prone to exercised-induced declines in muscle function because oft he importance of very-long-chain fatty acids to energy metabolism in exercise. The purpose of this project was to study muscle glycogen resynthesis in the recovery from high intensity exercise in VLCAD deficient mice. Recovery of skeletal muscle function (gastrocnemius) following exercise is not as rapid in …