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Kinesiology Commons

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Louisiana State University

LSU Doctoral Dissertations

2008

Exercise

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Exercise And Peripheral Vascular Function In Health And Disease, Arturo Arce Jan 2008

Exercise And Peripheral Vascular Function In Health And Disease, Arturo Arce

LSU Doctoral Dissertations

“Chronic disease will never reach its clinical horizon to compromise health if it is attacked at its origin” [1]. Knowledge that one’s risk for cardiovascular events is related to the severity of endothelial dysfunction, and evidence that exercise training can improve endothelial function, has prompted speculation that measures of vascular function may serve as a “barometer” for cardiovascular health. This dissertation consists of three experiments intended to study vascular function and the manner in which it may influence or may be influenced by physical function. Project one examined the influence of high and low volume circuit weight training on forearm …


Brachial Artery Flow Mediated Vasodilation: Effect Of Chemical Analytes, Diet, Exercise, And Genetic Markers, Joanie Brocato Wilson Jan 2008

Brachial Artery Flow Mediated Vasodilation: Effect Of Chemical Analytes, Diet, Exercise, And Genetic Markers, Joanie Brocato Wilson

LSU Doctoral Dissertations

The goal of this research was to gain a better understanding of interplay between molecular biology, physiology, biochemistry, functionality with disease and interventions. The primary findings of the first study were that there was a significant inverse correlation between homocysteine and brachial artery flow mediated dilation (BAFMD) and baseline brachial artery diameter. Interestingly, there was a significant difference in BAFMD between methylene tetrahydrofolate reductase (MTHFR) genotype groups. Regression analysis indicated that the MTHFR genotype, homocysteine and age were significant predictors of BAFMD. The second study revealed that vascular reactivity as measured by BAFMD was modifiable. A meta-analysis of 22 intervention …