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Full-Text Articles in Kinesiology
Regulation Of The Myostatin Protein In Overload-Induced Hypertrophied Rat Skeletal Muscle, Paige Abriel Affleck
Regulation Of The Myostatin Protein In Overload-Induced Hypertrophied Rat Skeletal Muscle, Paige Abriel Affleck
Theses and Dissertations
Myostatin (GDF-8) is the chief chalone in skeletal muscle and negatively controls adult skeletal muscle growth. The role of myostatin during overload-induced hypertrophy of adult muscle is unclear. We tested the hypothesis that overloaded adult rodent skeletal muscle would result in reduced myostatin protein levels. Overload-induced hypertrophy was accomplished by unilateral tenotomy of the gastrocnemius tendon in male adult Sprague-Dawley rats followed by a two-week period of compensatory overload of the plantaris and soleus muscles. Western blot analysis was performed to evaluate changes in active, latent and precursor myostatin protein levels. Significant hypertrophy was noted in the plantaris (494 ± …
Mtor Pathway Activation Following Resistance Exercise With Vibration In Human Subjects, Michael G. Leavitt
Mtor Pathway Activation Following Resistance Exercise With Vibration In Human Subjects, Michael G. Leavitt
Theses and Dissertations
Functional adaptations in human skeletal muscle following a period of resistance exercise are the result of regular activation of cellular signaling pathways that elevate muscle protein synthesis. It has been reported that the addition of whole body vibration (WBV) to a resistance exercise program enhances performance. Such improvements in muscle function may be the result of increased activation of cellular signaling pathways associated with muscle growth. Purpose: We have investigated whether an acute bout of resistance exercise in combination with WBV results in a greater activation of the mTOR signaling pathway compared to resistance exercise alone. Methods: Eight untrained college-age …