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Full-Text Articles in Kinesiology
Effect Of Myostatin Pathway Inhibition On Fibroblast Activity Using A Novel Small Molecule, Seth Hampton, Dr. Robert Hyldahl
Effect Of Myostatin Pathway Inhibition On Fibroblast Activity Using A Novel Small Molecule, Seth Hampton, Dr. Robert Hyldahl
Journal of Undergraduate Research
Fibroblasts play a key role in repairing injured tissue by secreting collagen and growth factors into the tissue. In states of disease and overuse, fibroblast activity can become overly abundant and can lead to skeletal muscle fibrosis, decreasing strength and muscle elasticity. This fibrotic condition can lead to muscle wasting disorders, such as muscular dystrophies, that severely decrease the length and quality of life. Previous studies have shown that the TGF-beta signaling family directly increases fibroblast proliferation. It has also been shown that inhibition of myostatin, a member of the TGF-beta family, reduces symptoms of muscular dystrophies and decreases fibrosis. …
Inhibition Of The Myostatin Signaling Pathway In Cultured Muscle Cells By A Novel Small Molecule, Ryan Matekel, Robert Hyldahl
Inhibition Of The Myostatin Signaling Pathway In Cultured Muscle Cells By A Novel Small Molecule, Ryan Matekel, Robert Hyldahl
Journal of Undergraduate Research
Muscle wasting is a symptom of cancer, AIDS, renal failure, heart failure, aging, prolonged bed rest, and has been seen in rodent models for burn, and kidney disease (Han, 2013). Muscle wasting negatively impacts quality of life by decreasing functional independence and increasing morbidity and mortality (Anker, 1997). Myostatin is a protein that negatively regulates muscle mass and is primarily expressed within skeletal muscle (Lee & McPherron, 2001). It exerts its effect by binding to a receptor and initiating a signaling cascade that involves phosphorylation of two kinase proteins called SMAD-2 and SMAD-3 (Sartori et al., 2009). Genetic studies have …