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Influence Of Cardiovascular Risk Factors On Remote Ischemic Preconditioning, Tiffany Trachte
Influence Of Cardiovascular Risk Factors On Remote Ischemic Preconditioning, Tiffany Trachte
Electronic Theses and Dissertations
A powerful therapy against microvascular endothelial ischemia-reperfusion injury is remote ischemic preconditioning (rIPC), which triggers tissue protection by exposing a limb to small cycles of vascular occlusion. Animal models indicate that CVD risk factors reduce the protective benefits of ischemic conditioning. However, there are no human studies investigating how a burden of risk factors interferes with rIPC to prevent endothelial injury. The purpose of the present study was to determine the influence of risk factor burden on the capacity of rIPC to prevent endothelial reperfusion injury in humans. Twenty-two (age: 45±14 yr., BMI: 31±8 kg/m2) sedentary adults (12 lower burden: …