Kinesiology Commons^™

The Role Of Protein Degradation In Cancer Cachexia In Female Tumor Bearing Mice, Noah Thomas

Graduate Theses and Dissertations

Background: Cancer is a leading cause of death in the world in which half of the people affected by this disease die from its effects. Cancer-cachexia is a syndrome associated with the significant loss of skeletal muscle mass and function, which cannot be fully reversed by nutritional intervention alone and in turn, impairs the host. Cancer-cachexia affects 50-80% of cancer patients and is a primary cause of death accounting for 20-40% of cancer related deaths. Efforts to reverse the effects of cancer-related cachexia have been largely unsuccessful and have primarily focused on the late stages of CC. Methods: Lewis Lung …

Changes In Hepatic Extracellular Matrix During The Development Of Cancer-Cachexia In Mice, Kyle Turner

Health, Human Performance and Recreation Undergraduate Honors Theses

CHANGES IN HEPATIC EXTRACELLULAR MATRIX DURING THE DEVELOPMENT OF CANCER-CACHEXIA IN MICE

Turner K.W.¹, Rosa-Caldwell M.E.¹, Brown J.L.¹, Lee D.E.¹, Perry R.A.¹, Haynie W.A.¹ Washington T.A.¹, Wiggs M.P.², Greene N.P.¹: ¹University of Arkansas, Fayetteville, Arkansas; ²Univeristy of Texas at Tyler, Tyler, Texas

BACKGROUND: Cancer is one of the most widespread and deadly diseases in recent history. Cancer-cachexia is a systemic, metabolic disorder that greatly disrupts the patient’s energy balance, causing uncontrollable weight and, specifically, skeletal muscle loss. This cancer-induced cachexia is …