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Immunology and Infectious Disease Commons™
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Full-Text Articles in Immunology and Infectious Disease
Cancer Salt Nostalgia, Aashish S. Allu, Venkataswarup Tiriveedhi
Cancer Salt Nostalgia, Aashish S. Allu, Venkataswarup Tiriveedhi
Biology Faculty Research
High-salt (sodium chloride) diets have been strongly associated with disease states and poor health outcomes. Traditionally, the impact of salt intake is primarily studied in cardiovascular diseases, hypertension and renal diseases; however, recently there has been increasing evidence demonstrating the role of salt in autoimmune diseases. Salt has been shown to modulate the inflammatory activation of immune cells leading to chronic inflammation-related ailments. To date, there is minimal evidence showing a direct correlation of salt with cancer incidence and/or cancer-related adverse clinical outcomes. In this review article, we will discuss the recent understanding of the molecular role of salt, and …
The Five Immune Forces Impacting Dna-Based Cancer Immunotherapeutic Strategy, Suneetha Amara, Venkataswarup Tiriveedhi
The Five Immune Forces Impacting Dna-Based Cancer Immunotherapeutic Strategy, Suneetha Amara, Venkataswarup Tiriveedhi
Biology Faculty Research
DNA-based vaccine strategy is increasingly realized as a viable cancer treatment approach. Strategies to enhance immunogenicity utilizing tumor associated antigens have been investigated in several pre-clinical and clinical studies. The promising outcomes of these studies have suggested that DNA-based vaccines induce potent T-cell effector responses and at the same time cause only minimal side-effects to cancer patients. However, the immune evasive tumor microenvironment is still an important hindrance to a long-term vaccine success. Several options are currently under various stages of study to overcome immune inhibitory effect in tumor microenvironment. Some of these approaches include, but are not limited to, …