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Immunology and Infectious Disease Commons™

Open Access. Powered by Scholars. Published by Universities.®

Animals

2009

Articles 1 - 3 of 3

Full-Text Articles in Immunology and Infectious Disease

Fighting Infection Fly-Style, Louisa Wu, Neal S. Silverman Dec 2009

Fighting Infection Fly-Style, Louisa Wu, Neal S. Silverman

Neal Silverman

No abstract provided.

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Nf-Kappab Signaling Pathways In Mammalian And Insect Innate Immunity, Neal S. Silverman, Tom Maniatis Dec 2009

Nf-Kappab Signaling Pathways In Mammalian And Insect Innate Immunity, Neal S. Silverman, Tom Maniatis

Neal Silverman

In this review, we discuss recent advances in understanding the signaling pathways in mammalian and Drosophila innate immunity, with emphasis on the mechanisms by which NF-kappaB/Rel family proteins are activated.

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Hormonal Regulation Of The Humoral Innate Immune Response In Drosophila Melanogaster, Thomas Flatt, Andreas Heyland, Florentina Rus, Ermelinda Porpiglia, Chris Sherlock, Rochele Yamamoto, Alina Garbuzov, Subba R. Palli, Marc Tatar, Neal S. Silverman Dec 2009

Hormonal Regulation Of The Humoral Innate Immune Response In Drosophila Melanogaster, Thomas Flatt, Andreas Heyland, Florentina Rus, Ermelinda Porpiglia, Chris Sherlock, Rochele Yamamoto, Alina Garbuzov, Subba R. Palli, Marc Tatar, Neal S. Silverman

Neal Silverman

Juvenile hormone (JH) and 20-hydroxy-ecdysone (20E) are highly versatile hormones, coordinating development, growth, reproduction and aging in insects. Pulses of 20E provide key signals for initiating developmental and physiological transitions, while JH promotes or inhibits these signals in a stage-specific manner. Previous evidence suggests that JH and 20E might modulate innate immunity, but whether and how these hormones interact to regulate the immune response remains unclear. Here we show that JH and 20E have antagonistic effects on the induction of antimicrobial peptide (AMP) genes in Drosophila melanogaster. 20E pretreatment of Schneider S2 cells promoted the robust induction of AMP genes, …

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