Immunology and Infectious Disease Commons^™

Correlation Of Gut Alteration With The Progression Of Experimental Autoimmune Encephalomyelitis (Eae) In C57bl/6 Mice, Al Anood Ahmed Al Naqbi

Theses

Background: Experimental autoimmune encephalomyelitis (EAE) is the mouse disease model of multiple sclerosis (MS), a chronic autoimmune disease targeting the central nervous system (CNS) resulting in neuroinflammation, neuroaxonal degeneration, and demyelination. Autoreactive CD4⁺ T cells are known for their role in the pathogenesis of MS. CD8⁺ T cells and NK cells were also found to be associated with the disease.

Aim: There is a limited number of studies investigating the link between gut alterations and immune cells in the gut influencing the outcome of the disease since the vast majority of MS patients experience gastrointestinal (GI) problems. Here, …

Factors Affecting The Antibacterial Activity Of Cefiderocol On Klebsiella Pneumoniae With Diverse Characteristics, Lana Jamal Rashed Daoud

Theses

Antimicrobial resistance (AMR) is a growing serious threat that poses a burden on the healthcare system. Spread of AMR bacteria limits treatment options; thus, new antimicrobial agents are required. Cefiderocol (CFDC) is a novel siderophore cephalosporin, approved by the FDA in 2019 for use in treating infections caused by multi-drug resistant (MDR) pathogens; but it is not yet in clinical use in the UAE. CFDC is equipped with stabilizers against β-lactamases as well as a siderophore side chain that allows it to penetrate the outer membrane of bacteria through the iron uptake pathways. The aim of this study is to …