Open Access. Powered by Scholars. Published by Universities.®
Immunology and Infectious Disease Commons™
Open Access. Powered by Scholars. Published by Universities.®
- Discipline
- Publication Type
Articles 1 - 2 of 2
Full-Text Articles in Immunology and Infectious Disease
Plasmacytoid Dendritic Cell-Mediated Humoral Autoimmunity, Stephanie M. Dorta-Estremera Ph.D.
Plasmacytoid Dendritic Cell-Mediated Humoral Autoimmunity, Stephanie M. Dorta-Estremera Ph.D.
Dissertations & Theses (Open Access)
Humoral autoimmunity is characterized by the breakdown of B cell immune tolerance to self-antigens and consequent production of pathogenic autoantibodies. Plasmacytoid dendritic cells (pDCs), a potent type I interferon (IFN-I) producer, have been linked to the pathogenesis of systemic lupus erythematosus (SLE), a prototypic systemic humoral autoimmune disease. However, the cellular events that stimulate the development of humoral autoimmunity as a result of pDC activation have not been characterized. Moreover, the B cell subset(s) responsible for the generation of autoantibodies remains to be clearly identified.
The immunization of DNA-containing amyloids into non-autoimmune mice triggers the activation of pDCs and induction …
Meningeal Infiltration Of The Spinal Cord By Non-Classically Activated B Cells Is Associated With Chronic Disease Course In A Spontaneous B Cell-Dependent Model Of Cns Autoimmune Disease, Amy K. Dang, Yodit Tesfagiorgis, Rajiv W. Jain, Heather C. Craig, Steven M. Kerfoot
Meningeal Infiltration Of The Spinal Cord By Non-Classically Activated B Cells Is Associated With Chronic Disease Course In A Spontaneous B Cell-Dependent Model Of Cns Autoimmune Disease, Amy K. Dang, Yodit Tesfagiorgis, Rajiv W. Jain, Heather C. Craig, Steven M. Kerfoot
Microbiology & Immunology Publications
We characterized B cell infiltration of the spinal cord in a B cell-dependent spontaneous model of central nervous system (CNS) autoimmunity that develops in a proportion of mice with mutant T and B cell receptors specific for myelin oligodendrocyte glycoprotein. We found that, while males are more likely to develop disease, females are more likely to have a chronic rather than monophasic disease course. B cell infiltration of the spinal cord was investigated by histology and FACs. CD4+ T cell infiltration was pervasive throughout the white and in some cases gray matter. B cells were almost exclusively restricted to …