Immunology and Infectious Disease Commons^™

Radiation-Induced Esophagitis Is Mitigated By Soy Isoflavones, Matthew Donovan Fountain

Wayne State University Theses

Lung cancer patients receiving radiotherapy present with acute and chronic esophagitis, resulting in pain and difficulties swallowing. These effects are due to radiation injury to the normal tissues in the esophagus. Our previous studies in pre-clinical models of lung cancer and naïve mice have shown that soy isoflavones alleviates radiation-induced toxicity to normal lung, including a decrease in pneumonitis and fibrosis. In this study, we have investigated whether radiation-induced esophagitis can be reduced by soy isoflavones. C57BL/6 mice were treated with 10 Gy or 25 Gy for thoracic irradiation and soy isoflavones given daily at 1mg/mouse up to 16 weeks. …