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Development And Maintenance Of Thymic Epithelial Microenvironment, Varan J. Singh
Development And Maintenance Of Thymic Epithelial Microenvironment, Varan J. Singh
Dissertations and Theses
Thymus is a primary lymphoid organ responsible for proper development and selection Of T-‐cells. The thymic microenvironment, however, undergoes age related involution, Resulting in a reduction of the repertoire of T-‐cells that are produced, and a decreased Capacity to respond to new antigen. Even though significant thymic epithelial turnover occurs, it is unclear if postnatal thymic progenitors/stem cell are responsible for the maintenance of the TEC microenvironment. Here we use the K5rtTA:TetO-‐H2BGFP transgenic model to identify a slow cycling potential stem cells/progenitor population in the postnatal thymus. These cells were isolated, expanded in culture, and successfully differentiated into adipocytes, chondrocytes …