Immunology and Infectious Disease Commons^™

The Role Of A Glycosyltransferase, St6gal I In Regulating Viral Specific T And B Cell Responses, Junwei Zeng

Doctoral Dissertations

Glycosylation is one of the most abundant post-translational modifications of proteins. Glycoproteins participate in virtually all aspects of cellular functions. ST6Gal I is a glycosyltransferase highly expressed by B and T cells. Here, we interrogated the role of ST6Gal I in viral specific B and T cell immune responses, as well as examined how loss of this enzyme impacted viral pathogenesis.

First, to understand how loss of ST6Gal I expression impacted viral specific humoral responses, we infected ST6Gal I^-/- mice with influenza virus. We discovered that loss of ST6Gal I expression results in both reduced influenza specific antibodies levels …