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Failure Of E. Coli Bacteria To Induce Preterm Delivery In The Rat, Emmet Hirsch, Yana Filipovich, Roberto Romero
Failure Of E. Coli Bacteria To Induce Preterm Delivery In The Rat, Emmet Hirsch, Yana Filipovich, Roberto Romero
Wayne State University Associated BioMed Central Scholarship
Abstract
Background
We sought to develop a model of bacterially induced preterm delivery in rats to parallel similar models in mice.
Methods
Female Sprague-Dawley rats on day 17 of gestation (normal term = 21–22 days) were inoculated into the uterus with either 2 × 109 – 7 × 1010 killed E. coli organisms, 1 – 4 × 108 live E. coli or sterile solution. These inoculations were made either via trans-cervical catheter or by direct intrauterine injection at laparotomy. Animals were then observed for delivery for variable periods up to term. Necropsies were performed and fetal viability …