Immunology and Infectious Disease Commons^™

Naive And Memory T Cell Trafficking In Selectin Ligand-Deficient Mice: The Role Of Fucosyltransferase –Iv And –Vii In The Differential Migration Of T Cell Populations, John Robert Harp

Masters Theses

The correct and timely delivery of immune cells is critical for protection against foreign antigen. In order for cells to access most organs, there are requirements that must be met to facilitate exit from the blood into extravasculature. The initial requirement is selectin-selectin ligand interactions that mediate tethering and rolling to allow shear resistance. For proper selectin-selectin ligand interaction, glycoproteins must be modified by fucosyltransferases –IV and –VII, which adds fucose to an acceptor substrate to form the sialyl-LewisX moiety. Using fucosyltransferase –IV and –VII double knockout (FtDKO) mice, we made several novel observations. Our first observation showed increased numbers …