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Immunology and Infectious Disease Commons™
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Full-Text Articles in Immunology and Infectious Disease
Discovery And Characterization Of Novel Antimicrobials Against Mycobacterium Tuberculosis, Carolina Rodrigues Felix
Discovery And Characterization Of Novel Antimicrobials Against Mycobacterium Tuberculosis, Carolina Rodrigues Felix
Electronic Theses and Dissertations
Tuberculosis disease is currently a global health emergency, causing the most deaths worldwide due a single infectious agent. Eradication of TB is hampered by lack of an effective vaccine and poor treatment options. During infection, host-derived cues such as hypoxia and starvation induce Mycobacterium tuberculosis to halt replication and become dormant, which leads to tolerance to front-line antibiotics used in the TB treatment. This dormant phenotype causes delayed clearance of M. tuberculosis, therefore a long treatment time is required for stable cure without relapse. Poor patient compliance increases the emergence of drug resistant strains, posing yet another challenge for the …
The Innate Anti-Hiv-1 Activity Of Human Seminal Plasma, Julie A. Martellini-Moore
The Innate Anti-Hiv-1 Activity Of Human Seminal Plasma, Julie A. Martellini-Moore
Electronic Theses and Dissertations
Human immunodeficiency virus (HIV) has become a global pandemic over the past few decades, with new infections and related deaths in the millions each year. There is no cure in sight for HIV-1 infection, and there has been little progress in developing an efficacious vaccine. Heterosexual transmission of HIV-1 remains the principal mode of transmission throughout the world and thus measures, such as topical vaginal microbicides, to prevent infection of the female reproductive tract are actively being explored. Recent trials of topical vaginal microbicides have shown that their interaction with the mucosal surfaces of the female reproductive tract as well …
Identification Of Novel Antimalarials From Marine Natural Products For Lead Discovery, Stephenie M. Alvarado
Identification Of Novel Antimalarials From Marine Natural Products For Lead Discovery, Stephenie M. Alvarado
Electronic Theses and Dissertations
An estimated 500 million cases of malaria occur each year. The increasing prevalence of drug resistant strains of Plasmodium in most malaria endemic areas has significantly reduced the efficacy of current antimalarial drugs for prophylaxis and treatment of this disease. Therefore, discovery of new, inexpensive, and effective drugs are urgently needed to combat this disease. Marine biodiversity is an enormous source of novel chemical entities and has been barely investigated for antimalarial drug discovery. In an effort to discover novel therapeutics for malaria, we studied the antimalarial activities of a unique marine-derived peak fraction library provided by Harbor Branch Oceanographic …