Immunology and Infectious Disease Commons^™

The Role Of Notch3 Signaling In T Helper Cell Differentiation And Induction Of Eae, Furkan Ayaz

Doctoral Dissertations

Th1 and Th17 are subsets of CD4⁺ T cells or T helper cells (Th). Th cells are the major adaptive immune cells involved in inflammation during the development of Multiple Sclerosis (MS). MS is a neurodegenerative autoimmune disease and one mouse model of the disease is Experimental Autoimmune Encephalomyelitis (EAE). Development and differentiation of Th1 and Th17 cells are regulated by the Notch family of trans-membrane proteins (Notch1, 2, 3 and 4). We and others have shown that pharmacological inhibition of Notch activity impairs Th1 and Th17 differentiation as well as development of EAE. However, it is not known …