Immunology and Infectious Disease Commons^™

Using Rainbow Trout Cell Lines As A Model For Understanding The Innate Anti-Fv3 Immune Response, Graeme Robert Jones Lisser

Theses and Dissertations (Comprehensive)

Ranavirus infections are on the rise and have been implicated in numerous species die-offs across the globe. Frog virus 3 (FV3) is the type-species of the genus, yet the immune mechanisms governing susceptibility remain poorly understood. Arguably the most important immune response to infection is the type I interferon (IFN) response. Type I IFNs trigger an “antiviral state” in host cells via the production of numerous interferon-stimulated genes (ISGs) that act to inhibit virus replication in various way, including the induction of apoptosis. Apoptosis is an important antiviral defense mechanism to limit virus replication within infected cells. This study employed …

Disease Models With Immigration, Reem Almarashi

Theses and Dissertations (Comprehensive)

In this thesis we focus first on studying the susceptible, exposed, and infected ($SEI$) disease model without immigration. We determine the basic reproduction number $\mathcal{R}_0$, which can be interpreted as the expected number of new cases that can be produced by a single infection in a completely susceptible population. Further, by using the Jacobian matrix, we determine the local stability of the disease model. Then we have the result that when $\mathcal{R}_0<1$ the DFE point is locally asymptotically stable(L.A.S). In contrast, when $\mathcal{R}_0>1$ we find that the endemic equilibrium is L.A.S. After that, we analyze the $SEI$ model with immigration of infected individuals.

Furthermore, we investigate the direction that the …