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Articles 1 - 2 of 2
Full-Text Articles in Immunology and Infectious Disease
The Effects Of Infliximab On The Fibrosis Response Of Three-Spine Stickleback, Mita Kale
The Effects Of Infliximab On The Fibrosis Response Of Three-Spine Stickleback, Mita Kale
Honors Scholar Theses
This study was conducted to determine if the monoclonal antibody drug infliximab could effectively suppress the fibrosis immune response in three-spine stickleback fish. Successful suppression of this response could allow for further study of cestode infection and growth without the presence of fibrosis. Infliximab’s efficacy was investigated through conducting two intraperitoneal injection experiments and examinations of the fibrosis in the body cavity of the euthanized stickleback. We used immune adjuvant alum to induce a fibrosis response without the presence of the S. solidus tapeworm parasite. Ultimately, the differences in fibrosis levels between the treatment groups that received alum and the …
Identifying The Cell Composition And Clonal Diversity Of Supratentorial Ependymoma Using Single Cell Rna-Sequencing, James He
University Scholar Projects
Ependymoma is a primary solid tumor of the central nervous system. Supratentorial ependymoma (ST-EPN), a subtype of ependymomas, is driven by an oncogenic fusion between the ZFTA and RELA genes in 70% of cases. We introduced this fusion into neural progenitor cells of mice embryos via in utero electroporation of a non-viral binary piggyBac transposon system containing ZFTA-RELA. From preliminary data in the LoTurco lab, inducing the expression of ZFTA-RELA into different neural progenitor cells produces tumors of varying lethality and cellular composition. To define the cellular composition and subclonal diversity of ST-EPN tumors, we used single cell RNA-sequencing to …