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Immunology and Infectious Disease Commons

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Full-Text Articles in Immunology and Infectious Disease

An Evolutionary Pathway For Coping With Emerging Infectious Disease, Scott Lyell Gardner, Daniel R. Brooks, Walter A. Boeger, Eric P. Hoberg Sep 2023

An Evolutionary Pathway For Coping With Emerging Infectious Disease, Scott Lyell Gardner, Daniel R. Brooks, Walter A. Boeger, Eric P. Hoberg

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Emerging infectious disease (EID) represents an existential threat to humanity. EIDs are increasing in frequency and impact because of climate change and other human activities. We are losing the battle against EIDs because of improper assessment of the risk of EID. This stems from adherence to a failed paradigm of pathogen-host associations that suggests EIDs ought to be both unpredictable and rare. That, in turn, leads to policies suggesting that crisis response is the best we can do. Real-time and phylogenetic assessments show EIDs to be neither rare nor unpredictable—this is the parasite paradox that shows the failures of the …


Data And R Code For "Gut Transplants From Bees Fed An Antipathogenic Pollen Diet Do Not Confer Pathogen Resistance To Recipients", Rachel T. Yost, Alison E. Fowler, Lynn S. Adler Jan 2023

Data And R Code For "Gut Transplants From Bees Fed An Antipathogenic Pollen Diet Do Not Confer Pathogen Resistance To Recipients", Rachel T. Yost, Alison E. Fowler, Lynn S. Adler

Data and Datasets

Pollinators are threatened by diverse stressors, including microbial pathogens such as Crithidia bombi. Consuming sunflower pollen dramatically reduces C. bombi infection in the bumble bee Bombus impatiens, but the mechanism behind this medicinal effect is unclear. We asked whether diet mediates resistance to C. bombi through changes in the gut microbiome. We hypothesized that sunflower pollen changes the gut microbiome, which in turn reduces Crithidia infection. To test this, we performed a gut transplant experiment. We fed donor bees either a sunflower pollen treatment or buckwheat pollen as a control treatment, and then inoculated recipient bees with homogenized guts …