Immunology and Infectious Disease Commons^™

Repurposing Cyclin-Dependent Kinase Inhibitors For The Discovery Of Novel Antiplasmodial Compounds, Ritam Bhowmik

Honors Undergraduate Theses

Malaria remains a major global health burden with over 282 million cases annually and rising resistance to artemisinin-based combination therapies. Plasmodium falciparum, the most lethal malaria parasite species in humans, relies on tightly regulated cell cycle progression during replication within red blood cells. Cyclin-dependent kinases (CDKs) are central regulators of eukaryotic cell division and transcription, and several CDK-like enzymes in P. falciparum, including Pfmrk and PfPK6, are essential for parasite growth and structurally distinct from human kinases. This study evaluated whether commercially available human CDK inhibitors (CDKIs) targeting cancer pathways could be repurposed as novel antimalarial compounds. A library of …

Early Intervention In Helminth Infections: Investigating Albendazole’S Effects On C. Elegans Egg Hatch Rate And Health, Giselle Domingo Diaz

Student Scholar Symposium

Over 1.5 billion of the poorest people are infected with soil-transmitted helminths (STH) such as whipworm, hookworm, and Ascaris which have devastating effects on human growth, nutrition, and cognition, perpetuating the cycle of poverty. The World Health Organization only approves four anthelmintic drugs to treat STH for mass drug administration (MDA), with Albendazole being the drug of choice. Due to these drugs only having two mechanisms of action, resistance to these drugs has been reported over the years. We aim to better understand STH susceptibility to drugs at multiple points in their life stage. Previously, the effects of Albendazole and …

Host, Microbiome, And Parasite: How Apicomplexan Microorganisms Interact With Gut Microbiota, Senia Bu, Andrew T. Ozga

Mako: NSU Undergraduate Student Journal

The gut microbiome, a complex ecosystem of microorganisms residing in the human gastrointestinal tract, plays a crucial role in maintaining overall health. It functions in immune system regulation, digestion, and protection against pathogens. Apicomplexan parasites, such as Toxoplasma gondii, Plasmodium spp., and Cryptosporidium spp., are major pathogens that can significantly disrupt the gut microbiota, leading to alterations in microbial composition and function. This review explores the bidirectional interactions between Apicomplexan parasites and the gut microbiome, focusing on how these parasites influence microbial diversity, immune responses, and host metabolism. It examines the mechanisms by which infection-induced inflammation, altered …

Spatially Resolved Transcriptomic Profiles Of Placental Cell Populations In Placental Malaria, Corina A. Mong

Undergraduate Honors Theses

Malaria remains a prevalent infectious disease that continues to cause disease-related morbidity and mortality. Despite preventative efforts, malarial pregnancies still cause birth complications, therefore emphasizing the necessity to study these adverse outcomes in malarial pregnancy. Malaria in pregnancy can lead to placental malaria (PM), which is the presence and accumulation of Plasmodium-infected red blood cells in the placental intervillous space (IVS). Even after treatment, past PM (presence of hemozoin crystals from the parasite in the placenta) can cause a chronic inflammatory response. We predicted that the activation states of the maternal monocytes and fetal macrophages differ within the placenta and …

Rwanda's Natural Remedies: A Fresh Look At The Fight Against Malaria, Leandre Nsabimana Ndisanze

Pomona Senior Theses

Malaria remains one of the most devastating parasitic diseases globally, disproportionately affecting sub-Saharan Africa, where Rwanda continues to face high transmission rates and rising resistance to conventional interventions. Despite decades of control efforts, the emergence of drug-resistant Plasmodium falciparum and insecticide-resistant Anopheles mosquitoes threatens to reverse recent gains. This research responds to the urgent need for sustainable and culturally relevant alternatives by exploring the therapeutic potential of Rwandan traditional medicinal plants. These indigenous remedies, long used by local healers, offer an underexplored reservoir of bioactive compounds that may provide the basis for novel antimalarial drugs.

The central hypothesis of this …

Schistosoma Mansoni Infection Causes Consistent Changes To The Fecal Bacterial Microbiota Of Mice Across And Within Sites, Mariam A. Mhanna, David T. Gauthier, Lisa M. Shollenberger

Biological Sciences Faculty Publications

Eggs of Schistosoma mansoni are produced by adult female worms in mesenteries of infected hosts. Eggs can cross the intestinal barrier and form granulomas in the tissue or breach and exit the host through fecal excretion. These interactions may affect the host microbiome assemblages. Given the potential for schistosomal alteration of host gut microbiome and subsequent effects on the fecal bacterial composition, it is important to conduct controlled microbiome studies on model animals. While pursuing these studies, it is important to take into account the different conditions in which microbiome studies are conducted and their consequent impacts on variability and …

Lupin Root Diseases - Diagnosis And Management, Department Of Primary Industries And Regional Development, Western Australia

Grains and other field crops factsheets

Root, hypocotyl and stem base diseases can be significant problems in lupin crops, reducing stand density, plant vigour and yield. Root disease is present in nearly all narrow leafed lupin (Lupinus angustifolius) paddocks but in the majority of paddocks has only a small impact on crop development. However, in paddocks where high levels of root rot occurs, plant establishment, seedling vigour and crop yield can be significantly affected.

When a root disease is present in a crop very little can be done to manage it in that cropping season. It is therefore vital that the cause is correctly identified to …

The Role Of Southern Red-Backed Voles, Myodes Gapperi, And Peromyscus Mice In The Enzootic Maintenance Of Lyme Disease Spirochetes In North Dakota, Usa, Michael W. Dougherty, Nathan M. Russart, Robert A. Gaultney, Emily Marie Gisi, Haley M. Cooper, Lindsey R. Kallis, Catherine A. Brissette, Jefferson A. Vaughan

Biology Faculty Publications

Lyme disease has expanded into the Great Plains of the USA. To investigate local enzootic transmission, small mammals were trapped in two forested tracts in northeastern North Dakota during 2012 and 2013. Peromyscus mice and southern red-backed voles, Myodes gapperi, comprised over 90% of all mammals captured. One site was dominated by Peromyscus (79% of 100 mammals captured). At the other site, M. gapperi (59% of 107 mammals captured) was more abundant than Peromyscus (36%). Immature stages of two tick species parasitized small mammals: Dermacentor variabilis and Ixodes scapularis. Larval I. scapularis ectoparasitism was significantly higher on Peromyscus (81% …

One Year Follow Up Of A Cross-Sectional Study Of Hookworm Infection And Response To Deworming In Beposo, Ghana, Taylor Clarkson

Capstone Experience: Master of Public Health

Hookworms are soil-transmitted helminths that infect over 500 million people worldwide, primarily those in low-income countries. Infection with hookworm can cause anemia, malnutrition, and stunted physical and cognitive development. Deworming campaigns have attempted to combat hookworm infections in endemic areas for decades. However, there is growing variability in the effectiveness of deworming drugs, and post-treatment reinfections are abundant. There are significant gaps in our understanding of critical host-parasite factors that mediate hookworm infection, reinfection, and response to deworming treatment in endemic communities. A five-year prospective study was undertaken to better understand drivers of hookworm infection in rural Ghana and thus …

Concepts In Animal Parasitology: Master Bibliography, Sue Ann Gardner

Concepts in Animal Parasitology

Master bibliography for the open educational resource/open access textbook Concepts in Animal Parasitology, Scott L. Gardner and Sue Ann Gardner, editors, published by Zea Books, Lincoln, Nebraska, United States, 2024. This includes the references from literature cited and suggested supplemental reading.

High Prevalence Of Trypanosoma Cruzi Infection In Raccoons (Procyon Lotor) And Associated Risk To Humans In Central Illinois, Esther Onuselogu

Masters Theses

Chagas disease, caused by the protozoan parasite Trypanosoma cruzi, remains a neglected tropical disease and a growing health threat in the United States. Raccoons (Procyon lotor) often coexist with humans in urban and suburban areas and serve as reservoir hosts for T. cruzi. While T. cruzi is rare in humans and domestic animals in the U.S., it is common in wildlife species, particularly raccoons and Virginia opossums (Didelphis virginiana). This study aimed to assess the prevalence of T. cruzi infection in the raccoon population of Central Illinois and evaluate the risk of transmission to humans. …

Assessing The Value And Knowledge Gains From An Online Tick Identification And Tick-Borne Disease Management Course For The Southeastern United States, Catherine A. Lippi, Holly D. Gaff, Alexis L. White, Sadie J. Ryan

Biological Sciences Faculty Publications

Background

Tick-borne diseases are a growing public health threat in the United States. Despite the prevalence and rising burden of tick-borne diseases, there are major gaps in baseline knowledge and surveillance efforts for tick vectors, even among vector control districts and public health agencies. To address this issue, an online tick training course (OTTC) was developed through the Southeastern Center of Excellence in Vector-Borne Diseases (SECOEVBD) to provide a comprehensive knowledge base on ticks, tick-borne diseases, and their management.

Methods

The OTTC consisted of training modules covering topics including tick biology, tick identification, tick-borne diseases, and public health, personal tick …

Concepts In Animal Parasitology, Chapter 31: Amphilinidea Poche 1922 (Order) [Platyhelminthes, Cestoda, Cestodaria], Klaus Rohde

Concepts in Animal Parasitology

An overview of the cestode (tapeworm) order Amphilinidea Poche, 1922, a large group of large endoparasitic worms infecting the body cavity of freshwater and marine teleost (bony) fishes and freshwater turtles. Covers the morphology of the adults and larvae and the life cycle of a representative species, Austramphilina elongata, and a discussion of other species in the group, including their taxonomy and phylogeny.

Chapter 31 in Concepts in Animal Parasitology by Klaus Rohde. 2024. S. L. Gardner and S. A. Gardner, editors. Zea Books, Lincoln, Nebraska, United States. doi: 10.32873/unl.dc.ciap031

Concepts In Animal Parasitology, Chapter 27: Litobothriidea Dailey, 1969 (Order) [Platyhelminthes, Cestoda, Eucestoda], Luis García-Prieto, Berenice Adán-Torres, Brenda Atziri García-García, Omar Lagunas-Calvo

Concepts in Animal Parasitology

An overview of the cestode (tapeworm) order Litobothriidea Dailey, 1969. The 9 species included in the order, all belonging to the genus Litobothrium, infect the spiral intestine of sharks in the order Lamniformes in the tropical eastern Pacific to the central Indo-Pacific marine ecoregions. Covers their main morphological characteristics, description and summary of a representative species, L. amplificum (Kurochkin and Slankis, 1973) Euzet, 1994, taxonomy, and life cycles.

Chapter 27 in Concepts in Animal Parasitology by Luis García-Prieto, Berenice Adán-Torres, Brenda Atziri García-García, and Omar Lagunas-Calvo. 2024. S. L. Gardner and S. A. Gardner, editors. Zea Books, Lincoln, …

Concepts In Animal Parasitology, Chapter 30: Relics Of “Tetraphyllidea” Van Beneden, 1850 (Order) [Platyhelminthes, Cestoda, Eucestoda], Berenice Adán-Torres, Omar Lagunas-Calvo, Brenda Atziri García-García, Luis García-Prieto

Concepts in Animal Parasitology

An overview of the relics of cestode (tapeworm) order “Tetraphyllidea” van Beneden, 1850, parasites found in the spiral intestine and occasionally the stomach of species from all orders of elasmobranch fishes. Includes a discussion of their main morphological characteristics, a description and summary of a representative species, Duplicibothrium cairae Ruhnke et al., 2000, taxonomy, and life cycle.

Chapter 30 in Concepts in Animal Parasitology by Berenice Adán-Torres, Omar Lagunas-Calvo, Brenda Atziri García-García, and Luis García-Prieto. 2024. S. L. Gardner and S. A. Gardner, editors. Zea Books, Lincoln, Nebraska, United States. doi: 10.32873/unl.dc.ciap030

Concepts In Animal Parasitology, Chapter 32: Gyrocotylidea (Order): The Most Primitive Group Of Tapeworms [Platyhelminthes, Cestoda, Cestodaria], Willi E. R. Xylander, Klaus Rohde

Concepts in Animal Parasitology

An overview of the cestode order Gyrocotylidea, the most primitive group of tapeworms, including a discussion of their taxonomy, a description of the structure of the adult and the larva, life cycle, and ecological and economic importance.

Chapter 32 in Concepts in Animal Parasitology by Willi E. R. Xylander and Klaus Rohde. 2024. S. L. Gardner and S. A. Gardner, editors. Zea Books, Lincoln, Nebraska, United States. doi: 10.32873/unl.dc.ciap032

Concepts In Animal Parasitology, Chapter 33: Aspidogastrea (Subclass) [Platyhelminthes, Trematoda, Aspidogastrea], Klaus Rohde

Concepts in Animal Parasitology

An overview of the trematode (fluke) subclass Aspidogastrea, a very small group of trematodes with around 80 species, none of them of economic importance, but are of great interest because of their unique structure, their simple life cycles (which may well be the most primitive or ancestral one among the trematodes, and the extraordinarily complex sensory/nervous systems found in some species. Includes a desciption of their general morphology, life cycles, taxonomy and phylogeny, infection process, localization in the host, and ecological infection dynamics.

Chapter 33 in Concepts in Animal Parasitology by Klaus Rohde. 2024. S. L. Gardner and S. A. …

Concepts In Animal Parasitology, Chapter 34: Introduction To Diplostomida Olson Et Al., 2003 (Order) [Platyhelminthes, Trematoda, Digenea, Diplostomida], Lucrecia Acosta Soto, Bernard Fried, Rafael Toledo

Concepts in Animal Parasitology

An introduction to the trematode (fluke) order Diplostomida Olson et al., 2003, one of the two main lineages from which subclass Digenea have diversified. Includes a discussion of Diplostomida systematics, general morphology, and human pathogenesis, including schistosomiasis.

Chapter 34 in Concepts in Animal Parasitology, by Lucrecia Acosta Soto, Bernard Fried, and Rafael Toledo. 2024. S. L. Gardner and S. A. Gardner, editors. Zea Books, Lincoln, Nebraska, United States. doi: 10.32873/unl.dc.ciap034

Concepts In Animal Parasitology, Chapter 36: Introduction To Plagiorchiida La Rue, 1957 (Order)[Platyhelminthes, Trematoda, Digenea, Plagiorchiida], Rafael Toledo, Bernard Fried, Lucrecia Acosta Soto

Concepts in Animal Parasitology

An introduction to the large trematode (fluke) order Plagiorchiida La Rue, 1957, one of two fundamental branches of the Digenea (along with the Diplostomida). Includes a classification and basic morphological characteristics.

Chapter 36 in Concepts in Animal Parasitology, by Rafael Toledo, Bernard Fried, and Lucrecia Acosta Soto. 2024. S. L. Gardner and S. A. Gardner, editors. Zea Books, Lincoln, Nebraska, United States. doi: 10.32873/unl.dc.ciap036

Concepts In Animal Parasitology, Chapter 38: Echinostomata La Rue, 1926 (Suborder) [Platyhelminthes, Trematoda, Digenea, Plagiorchiida], Rafael Toledo, Bernard Fried, Lucrecia Acosta Soto

Concepts in Animal Parasitology

An overview of the trematode (fluke) suborder Echinostomata La Rue, 1926, which includes numerous species of trematodes that are parasites of humans and domestic animals and are of great health significance. Includes taxonomy, general morphological characteristics, identification, and life cycles for several groups, as well as brief discussions of human echinostomiasis, fascioliasis, and fasciolopsiasis.

Chapter 38 in Concepts in Animal Parasitology, by Rafael Toledo, Bernard Fried, and Lucrecia Acosta Soto. 2024. S. L. Gardner and S. A. Gardner, editors. Zea Books, Lincoln, Nebraska, United States. doi: 10.32873/unl.dc.ciap038

Concepts In Animal Parasitology, Chapter 35: Aporocotylidae Odhner, 1912 (Family): Fish Blood Flukes [Platyhelminthes, Trematoda, Digenea, Diplostomida], Russell Q.-Y. Yong

Concepts in Animal Parasitology

An overview of the trematode family Aporocotylidae Odhner, 1912, also known as the fish blood flukes. Covers identification methods, general morphology, taxonomy, life cycles, and effect on the aquaculture industry.

Chapter 35 in Concepts in Animal Parasitology, by Russell Q.-Y. Yong. 2024. S. L. Gardner and S. A. Gardner, editors. Zea Books, Lincoln, Nebraska, United States. doi: 10.32873/unl.dc.ciap035

Concepts In Animal Parasitology, Chapter 39: Haplosplanchnata Olson Et Al., 2003 (Suborder): Two Hosts With Half The Guts [Platyhelminthes, Trematoda, Digenea, Plagiorchiida], Daniel C. Huston

Concepts in Animal Parasitology

An overview of the suborder Haplosplanchnata Olson et al., 2003, a small, but distinct lineage within the Plagiorchiida. Includes a discussion of the methods of identification, general morphological characteristics, taxonomy, and life cycles.

Chapter 39 in Concepts in Animal Parasitology, by Daniel C. Huston. 2024. S. L. Gardner and S. A. Gardner, editors. Zea Books, Lincoln, Nebraska, United States. doi: 10.32873/unl.dc.ciap039

Concepts In Animal Parasitology, Chapter 37: Bivesiculata Olson Et Al., 2003 (Suborder): Small, Rare, But Important [Platyhelminthes, Trematoda, Digenea, Plagiorchiida], Thomas H. Cribb, Scott C. Cutmore

Concepts in Animal Parasitology

An overview of the the small, rare, but important group of trematodes (flukes) in suborder Bivesiculata Olson et al., 2003, found in the intestine of marine bony fishes in the class Osteichthyes. Includes identification methods, general morphology, life cycles, and taxonomy.

Chapter 37 in Concepts in Animal Parasitology by Thomas H. Cribb and Scott C. Cutmore. 2024. S. L. Gardner and S. A. Gardner, editors. Zea Books, Lincoln, Nebraska, United States. doi: 10.32873/unl.dc.ciap037

Concepts In Animal Parasitology, Chapter 40: Hemiurata Skrjabin & Guschanskaja, 1954 (Suborder) [Platyhelminthes, Trematoda, Digenea, Plagiorchiida], Lucrecia Acosta Soto, Bernard Fried, Rafael Toledo

Concepts in Animal Parasitology

An overview of the trematode (fluke) suborder Hemiurata Skrjabin & Guschanskaja, 1954, one of the most diverse groups of digeneans. They usually occur in the stomach and intestine mainly of marine teleost fishes but also in freshwater teleosts, elasmobranchs, amphibians, and reptiles, and have a wide geographical distribution, found in the Great Barrier Reef of Australia, the Indian Ocean, and the Atlantic Ocean. Includes discussion of general morphological characteristics, taxonomy, and life cycles.

Chapter 40 in Concepts in Animal Parasitology, by Lucrecia Acosta Soto, Bernard Fried, and Rafael Toledo. 2024. S. L. Gardner and S. A. Gardner, editors. Zea Books, …

Concepts In Animal Parasitology, Chapter 42: Opisthorchis (Genus) [Platyhelminthes, Trematoda, Digenea, Plagiorchiida], Sue Ann Gardner

Concepts in Animal Parasitology

A very brief overview of the trematode (fluke) genus Opisthorchis, including taxonomy, human medical importance, and life cycle.

Chapter 42 in Concepts in Animal Parasitology, compiled by Sue Ann Gardner from information from the United States Centers for Disease Control and Prevention, Division of Parasitic Diseases and Malaria. 2024. S. L. Gardner and S. A. Gardner, editors. Zea Books, Lincoln, Nebraska, United States. doi: 10.32873/unl.dc.ciap042

Concepts In Animal Parasitology, Chapter 43: Allocreadiidae Looss, 1902 (Family) [Platyhelminthes, Trematoda, Digenea, Plagiorchiida, Xiphidiata], Gerardo Pérez-Ponce De León, David Iván Hernández-Mena, Brenda Solórzano-García

Concepts in Animal Parasitology

An overview of the trematode (fluke) family Allocreadiidae Looss, 1902, mainly found as parasites of the digestive tracts of freshwater fishes. Includes a discussion of the taxonomy and classification, main morphological characteristics, morphological variability, life cycle, population biology, phylogenetic relationships, species diversity, and descriptions of representative species.

Chapter 43 in Concepts in Animal Parasitology, by Gerardo Pérez-Ponce de León, David Iván Hernández-Mena, and Brenda Solórzano-García. 2024. S. L. Gardner and S. A. Gardner, editors. Zea Books, Lincoln, Nebraska, United States. doi: 10.32873/unl.dc.ciap043

Concepts In Animal Parasitology, Chapter 44: Haematoloechidae Odening, 1964 (Family) [Platyhelminthes, Trematoda, Digenea, Plagiorchiida, Xiphidiata], Virginia León-Règagnon

Concepts in Animal Parasitology

An overview of the trematode (fluke) family Haematoloechidae Odening, 1964, parasites of the lungs of amphibians that are found on every continent except Antarctica. Their life cycle includes a snail and an aquatic arthropod as first and second intermediate hosts, respectively, and a frog or salamander as the definitive host. Includes a discussion of the main characters, taxonomy, phylogenetics, life cycles, host range, and biogeography.

Chapter 44 in Concepts in Animal Parasitology, by Virginia León-Règagnon. 2024. S. L. Gardner and S. A. Gardner, editors. Zea Books, Lincoln, Nebraska, United States. doi: 10.32873/unl.dc.ciap044

Concepts In Animal Parasitology, Chapter 45: Lecithodendriidae Lühe, 1901 (Family) [Platyhelminthes, Trematoda, Digenea, Plagiorchiida, Xiphidiata], Jeffrey M. Lotz

Concepts in Animal Parasitology

An overview of the trematode (fluke) family Lecithodendriidae Lühe, 1901, which inhabit the intestinal tract of insectivorous bats and occasionally birds. Includes a discussion of identification, general morphological charcteristics, systematics, taxonomy, life cycles, human and veterinary health significance, and ecology.

Chapter 45 in Concepts in Animal Parasitology, by Jeffrey M. Lotz. 2024. S. L. Gardner and S. A. Gardner, editors. Zea Books, Lincoln, Nebraska, United States. doi: 10.32873/unl.dc.ciap045

Concepts In Animal Parasitology, Chapter 46: Opecoelidae Ozaki, 1925 (Family): The Richest Trematode Family [Platyhelminthes, Trematoda, Digenea, Plagiorchiida, Xiphidiata], Storm B. Martin

Concepts in Animal Parasitology

An overview of the trematode (fluke) family Opecoelidae Ozaki, 1925, the richest of all trematode families, comprising over 1,000 described species presently arranged into about 100 genera. Adult opecoelids are benign endoparasites, typically residing in the intestines, pyloric ceca, or rectum of phylogenetically and ecologically diverse teleost fishes worldwide. They exploit both marine and freshwater fishes and are among the best represented trematode lineages known from polar and deep sea fishes. Therefore, although no opecoelids are known to have any economic importance, they are often among the lineages of trematodes most frequently encountered by ichthyoparasitologists in the field.

Includes a …

Concepts In Animal Parasitology, Chapter 41: Monorchiata Olson Et Al., 2003 (Suborder): Two Families Separated By Salinity [Platyhelminthes, Trematoda, Digenea, Plagiorchiida], Nicholas Q.-X. Wee

Concepts in Animal Parasitology

An overview of the speciose trematode (fluke) suborder Monorchiata Olson et al., 2003, which parasitizes fishes as adults. Includes general morphology, systematics, taxonomy, life cycles, and biogeography for several groups.

Chapter 41 in Concepts in Animal Parasitology, by Nicholas Q.-X. Wee. 2024. S. L. Gardner and S. A. Gardner, editors. Zea Books, Lincoln, Nebraska, United States. doi: 10.32873/unl.dc.ciap041