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Developing A Nasal Organotypic Model To Investigate The Effects Of The Nasal Microbiome On Susceptibility To Pathogens, Victor H.K. Lam Mr.
Developing A Nasal Organotypic Model To Investigate The Effects Of The Nasal Microbiome On Susceptibility To Pathogens, Victor H.K. Lam Mr.
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The microbiota is essential to the functioning of the immune system. The nasal milieu secretes immune molecules that can be influenced by diverse bacteria. Hence commensals that enhance anti-viral responses may confer resistance to respiratory viral infection.
Our collaborators have identified 7 microbial state types (CST) defined by indicator species in the nose and recently, through analyses of nasal immune molecules, we have categorized the nasal immune profile types into 8 groups (IPT). Although the IPTs correlated with certain CSTs, the influence of the nasal microbiome on susceptibility to respiratory pathogens is still unknown.
Defining this complex relationship requires a …